The University of California, Los Angeles (UCLA), through its Office of Research Administration, received a $1,354,522 project grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) to develop a biosensor for real-time visualization of the spatiotemporal dynamics of the key cellular metabolite acetyl-CoA. The project aims to overcome limitations in understanding the compartmentalized regulation of acetyl-CoA, a central metabolite involved in diverse biochemical processes, by utilizing live-cell imaging with genetically encoded fluorescent biosensors. This work will enhance the understanding of acetyl-CoA dynamics and signaling networks that regulate its subcellular localization, with the expected outcomes of introducing a new tool to study cellular metabolism in real-time. The project period runs from September 1, 2023 to August 31, 2026.
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