Project Grant DP2AI201027
Award Date 8/1/26
Completion Date 7/31/31
Dollars Obligated $460K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Los Angeles, CA 90095, USA
Similar Awards
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University a $1,279,395 cooperative agreement on August 1, 2026, to investigate fundamental mechanisms governing the induction of antigen-specific IgA in the gastrointestinal tract under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project examines two distinct pathways generating affinity-matured gut IgA following oral immunization with protein antigens. The first pathway,...
- The National Institute of Allergy and Infectious Diseases awarded New York University a Project Grant of $791,797 on February 4, 2026, to investigate intestinal programming of gut-associated germinal centers under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research examines how the intestinal microbiota directs differential programming of local B cell responses toward production of regulatory immunoglobulin A (IgA) in gut-associated germinal centers. IgA, produced by...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, Los Angeles $744,483 on June 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how epigenetic heterogeneity and temporal signaling dynamics in B-cell selection shape antibody repertoires and vaccine responses. The funded research examines B-cell fate decisions during antibody-mediated immunity through two primary aims. Aim 1 investigates how dynamic...
- The National Institute of Allergy and Infectious Diseases awarded The University Corporation $147,500 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will conduct research to define the genomic and metabolic determinants by which select Akkermansia species and strains degrade non-fucosylated core human milk oligosaccharides (HMOs) during growth, and to identify ecological interactions among Akkermansia and other HMO-degrading bacteria...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, Berkeley $156,104 under the Allergy and Infectious Diseases Research program on March 9, 2026, to investigate how gut bacteria mitigate Shigella infection through bacterial culturing and gnotobiotic mouse models. The research examines the effects of various gut bacteria on Shigella growth and virulence through growth curve assays and fluorescent reporter plasmid techniques, with focus on how commensal...
- The National Institute of Allergy and Infectious Diseases awarded the University of Massachusetts Medical School $251,250 on September 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research into the generation and tissue maintenance of splenic IgA plasma cells. The research investigates how B lymphocytes responding to commensal microbes in the gut generate IgA-secreting plasma cells that localize to the spleen and other systemic sites. IgA is...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, Los Angeles $196,020 on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define distinct mechanisms of interferon gamma trained immunity. The research investigates how interferon gamma (IFNG), a cytokine secreted by T cells in response to infection, drives trained immune memory—the ability of innate immune cells to retain memory of prior stimuli. The project...
- The National Institute of Allergy and Infectious Diseases awarded $234,151 to the University of California, Davis on August 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the mechanism of mRNA polyadenylation in immunoglobulin heavy chain genes during the differentiation of activated B cells into plasma cells. The research leverages single-cell-level RNA measurement coupled with RNA hybridization-based flow cytometry and CRISPR-based genome...
- The National Institute of Allergy and Infectious Diseases awarded Baylor University $561,968 on July 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of microbial-derived indoles in controlling Fusobacterium nucleatum virulence and host immune responses. The research determines the metabolic pathways contributing to indole-3-aldehyde and indole-3-carboxylic acid production in the human gut microbiome using computational gene annotation,...
- The National Institute of Allergy and Infectious Diseases awarded Duke University $684,405 on July 22, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop mucosal immunotherapies targeting recurrent urinary tract infections and inflammatory bowel disease. The funded research advances immunomodulation via self-assembled peptides (ISAP), a platform using modular supramolecular polypeptide nanomaterials designed to elicit neutralizing antibody responses against...