Project Grant DP2AI200954
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $3.15 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 1, 2025, with completion scheduled for August 31, 2029. The award supports investigator-initiated biomedical research examining the role of dendritic cell intrinsic unfolded protein response (UPR) pathways in driving...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $441,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 1, 2025, with a completion date of July 31, 2027. The award supports basic immunological research investigating the cell-specific roles of CD153 and CD30 in regulating immune responses, with particular focus on age-related immune...
- The National Institute of Allergy and Infectious Diseases awarded Cincinnati Children's Hospital Medical Center (doing business as Children's Home Healthcare) $703,409 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of the CLIC/GEEC endocytic pathway in virus-containing compartment (VCC) formation and HIV-1 transmission from macrophages. The research defines mechanisms by which myeloid cells internalize HIV-1 particles and...
- The National Institute of Allergy and Infectious Diseases awarded Cincinnati Children's Hospital Medical Center $758,906 on July 22, 2026, to conduct research under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds the Syndrome of Undifferentiated Recurrent Fevers: Understanding Phenotypes (SURFS-UP) study, which seeks to define distinct proinflammatory transcriptional phenotypes across the immune landscape in patients with syndrome of undifferentiated recurrent...
- The National Institute of Allergy and Infectious Diseases awarded Cincinnati Children's Hospital Medical Center $243,000 on July 15, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate cellular immune mechanisms underlying chronic post-surgical pain in adolescents. The research elucidates mechanistic links between immune signatures and sensory neuron excitability in chronic postsurgical pain (CPSP) pathogenesis. The study leverages banked serum and...
- The National Institute of Allergy and Infectious Diseases awarded Cincinnati Children's Hospital Medical Center $202,500 on June 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R21AI200165). The award funds basic research examining how peroxisomes and peroxisomal fatty acid β-oxidation regulate CD4+ T cell inflammatory responses and shape disease pathogenesis in inflammatory and autoimmune conditions. The research investigates the role of...
- Federal Project Grant Award Summary Cincinnati Children's Hospital Medical Center received a $441,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 12, 2025, with a completion date of July 31, 2027. This grant supports investigator-initiated biomedical research examining the transcriptional mechanisms of chronic inflammation in genetically diverse tissue macrophages,...
- The National Institute of Allergy and Infectious Diseases awarded the University of Connecticut Health Center $825,050 on June 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate glycosylated RNA (glycoRNA) control of immune homeostasis. The funded research tests the hypothesis that glycosylation of mammalian small RNAs prevents immune sensing of glycoRNAs by shielding them from endosomal toll-like receptor (TLR) sensing machinery. The work proceeds...
- The National Institute of Allergy and Infectious Diseases awarded Cincinnati Children's Hospital Medical Center $168,296 on October 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of growth hormone and STAT2 in modulating neuroimmune signaling and mast cell recruitment in neonatal inflammatory pain. The research uses nerve-targeted gene knockdown strategies in neonates with carrageenan-induced hind paw muscle inflammation to test the...
- The National Institute of Allergy and Infectious Diseases awarded The Children's Hospital of Philadelphia $906,255 on July 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to discover and characterize novel genes regulating follicular helper T cell function in antibody responses. The research combines variant-to-gene mapping approaches in human follicular helper T cells to identify disease-associated genetic variation influencing B cell antibody responses. Aim...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded Cincinnati Children's Hospital Medical Center (doing business as Children's Home Healthcare) a project grant of $486,000 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into riboregulation of innate immune signaling, specifically the role of RNA in organizing and regulating multiprotein signaling complexes called signalosomes. The research will develop broadly applicable tools to manipulate RNA-protein interactions in living cells and in vitro, then deploy these tools to study two key immune signalosomes: the myddosome involved in Toll-like receptor and interleukin-1 receptor signaling, and the CARD-BCL10-MALT1 signalosome that mediates antifungal responses through C-type lectin receptors. The work will dissect the mechanistic role of RNA interaction at these complexes during immune signaling and uncover novel RNA-associated proteins in antifungal signaling pathways. Performance is based in Cincinnati, Ohio 45229. The award period runs through August 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $486.0k | 8/18/26 |