This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $197,646 to the University of California, San Diego (UC San Diego) to conduct research on enhancing bacteriophage function with coevolution and synthetic biology. The overall objective is to use experimental evolution to identify genetic changes in phages that enhance their ability to suppress bacterial growth,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $233,250 to the University of North Carolina at Chapel Hill to perform key proof-of-concept research on a novel bacteriophage-based delivery platform for microbiome engineering. The goal is to develop and characterize self-circulating non-replicative phage vectors (SCNRPVs) capable of safely and efficiently transducing...
This $821,426 Project Grant, awarded on January 16, 2025 by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health, is funding research to develop nanostructures that selectively target bacteria and create computational models to predict their activity and behavior. The key objectives are to: Use computer-guided design to create and test antimicrobial nanostructures against...
The University of Rochester was awarded a $462,000 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to investigate how the microbiome in healthy human blood differentially "primes" or trains neutrophils, leading to varied inflammatory responses during sepsis. The research aims to elucidate the mechanisms underlying this microbiome-mediated immune...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $1,144,714 to the University of Illinois to conduct research aimed at discovering novel antibiotics for gram-negative pathogens. The primary goals are to identify physicochemical traits that allow antibiotics to evade efflux pumps in E. coli, P. aeruginosa, and A. baumannii, and then apply this knowledge to develop at...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $453,750 to Tufts University School of Medicine to study how certain bacteriophages (viruses that infect bacteria) evade the protective mechanisms of bacteria, including some deadly pathogens like Vibrio cholerae. The project aims to determine the counter-defense mechanisms used by these phages and identify the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $1,438,589 to the University of Colorado-Denver to develop high-throughput methods that measure and identify DNA transduction within bacterial pathogens and microbiomes. The project aims to examine how transduction, the transfer of genetic material by bacterial viruses or virus-like particles, spreads virulence traits within the microbiota. A...
This $402,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy to investigate the structure, dynamics, and interactome of biomolecular condensates in bacteria. The project, being conducted at New York University, will apply this "opto-proteomic toolbox" to understand the role of...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,388,838 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Research Foundation For The State University Of New York (RF SUNY) to optimize phage cocktail regimens for treating extensively drug-resistant Pseudomonas aeruginosa. The project aims to: 1) develop a quantification assay for the phage cocktail, 2) identify optimal phage combinations and administration patterns...
This $948,482 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research into the molecular mechanisms of the YbtPQ bacterial importer, a novel type of ATP-binding cassette (ABC) transporter found in uropathogenic E. coli. The primary goals are to define the substrate selectivity and inhibitory mechanisms of YbtPQ, as well as understand its unique structural motifs. Researchers at the University of...