Project Grant 80NSSC18K0056
- The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $399,146 Project Grant to the Regents of the University of Michigan under the Engineering program (CFDA 47.041) to develop a bioreactor system for conducting research on the effects of microgravity and aging on neuromuscular function. The objectives are to evaluate force generation and reactive oxygen species production in tissue-engineered human nerve-muscle constructs,...
- This $400,000 Project Grant award from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), under CFDA 47.041 Engineering program, will fund The Johns Hopkins University to develop engineered heart tissue chips for testing nanoparticle-based countermeasures against spaceflight-induced heart disease. The research aims to investigate whether nanoparticles designed to scavenge reactive oxygen species can prevent mitochondrial...
- The National Science Foundation awarded a $399,685 project grant to the University of California Irvine under the Engineering program (CFDA 47.041) to develop innovative cartilage tissue engineering strategies utilizing the microgravity environment of the International Space Station. The objectives of the three-year award beginning September 1, 2022 include employing microgravity conditions to enhance key processes in earth-based cartilage tissue engineering such as redifferentiation of expanded...
- This $350,000 National Science Foundation project grant supports research at the University of Virginia from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to advance understanding of the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, endothelial network formation, and extracellular matrix...
- This federal Project Grant award, provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), supports a research project at Temple University to investigate how microgravity and radiation exposure impact the function of engineered human adipose (fat) tissue. The $399,994 award, with a performance period from December 2024 to November 2027, will involve sending engineered adipose tissue samples to the International Space Station (ISS) for a 6-month study. The...
- This $382,124 federal Project Grant award, made by the National Science Foundation's Engineering program (CFDA 47.041), aims to advance tissue engineering and in-space cell technologies for regenerative medicine applications. The award will fund a collaborative effort between Micro-Grx, Inc., the University of Florida, Ronawk, and Redwire to develop three-dimensional "bio-block" tissue models that mimic the vascularization of heart and skin cells. These bio-block organoids will be used...
- Federal Cooperative Agreement Summary Cedars-Sinai Medical Center received a $1.2 million cooperative agreement from the National Institute on Aging (Aging Research program, CFDA 93.866) effective August 15, 2025, through July 31, 2030, to develop microphysiological systems (MPS), or organ-on-chip models, for studying spaceflight-induced aging and inflammaging. The research will establish human induced pluripotent stem cell (hiPSC)-derived, multi-lineage gut, brain, and heart MPS systems...
- This $400,000 National Science Foundation project grant supports research at Tufts University aimed at understanding the impact of aging on wound healing processes. Specifically, the grant funds two years of research to determine the effects of microgravity on fibroblast phenotype and wound healing response across tissue types and developmental ages. Investigators will leverage the unique environment of the International Space Station to simulate aging processes and their influence on tissue...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- The University of California, San Diego will receive $400,000 from the National Science Foundation under the Engineering (CFDA 47.041) federal grant program to research the mechanisms of microgravity accelerated aging on human brain organoids from October 1, 2021 to September 30, 2024. Through this three-year Project Grant, UCSD researchers will study how microgravity exposure impacts the aging process in miniaturized human brain tissues grown in a laboratory, with the goal of furthering...
LONG DURATION SPACE EXPLORATION MISSIONS CAUSE ASTRONAUTS TO EXPERIENCE PHYSIOLOGICAL DECONDITIONING INCLUDING BONE LOSS MUSCLE ATROPHY CARDIOVASCULAR DECONDITIONING SENSORIMOTOR/BALANCE IMPAIRMENT AND VISION CHANGES. FOR A CREWED MARS MISSION WHERE MICROGRAVITY AND REDUCED GRAVITY (E.G. 0.38 G ON THE MARTIAN SURFACE) EXPOSURE MAY OCCUR FOR 2+ YEARS DECONDITIONING IMPACTS THE ASTRONAUTS HEALTH WELL-BEING EFFECTIVENESS AND SAFETY. HERE WE PROPOSE A NOVEL LINEAR ARTIFICIAL GRAVITY (AG) TECHNOLOGY DESIGNED TO COUNTERACT THESE DELETERIOUS EFFECTS ON THE ASTRONAUTS. PREVIOUS CENTRIFUGE AG SYSTEMS HAVE NEGATIVE IMPACTS DUE TO THE CONSTANT ROTATING ENVIRONMENT: 1) CORIOLIS FORCES WHICH MAY BE CONFUSING AND LIMIT CONCURRENT EXERCISE OR LEAD TO INJURY 2) VESTIBULAR CROSSCOUPLING ILLUSIONS WHICH ARE HIGHLY PROVOCATIVE AND CAUSE MOTION SICKNESS AND 3) GRAVITY GRADIENTS WHERE THE LOADING VARYING ALONG THE LENGTH OF THE ASTRONAUTS BODY. ALTERNATIVELY OUR LINEAR AG TECHNOLOGY (TERMED TURBOLIFT ) SUFFERS FROM NONE OF THESE CONFOUNDING PROBLEMS PARTICULARLY DURING THE ACCELERATION/DECELERATION LOADING PHASES. BRIEFLY THE CONCEPTUAL PARADIGM IS AS FOLLOWS: THE ASTRONAUT IS LINEARLY ACCELERATED AT 1G FOR ~1S THEN IS ROTATED 180 DEGREES TO PREPARE FOR A 1G DECELERATION FOR ~1S. THIS PROCESS IS REPEATED TO CREATE INTERMITTENT AG WHERE THE FORCE IS ALWAYS HEADWARD SIMILAR TO STANDING HERE ON EARTH. THE EXPERIENCE IS LIKELY TO BE ANALOGOUS TO BOUNCING MILDLY ON A TRAMPOLINE. THE INTERMITTENT LOADING IS INTENDED TO REDUCE OR ELIMINATE THE PHYSIOLOGICAL DECONDITIONING IN A COMPREHENSIVE MULTI-SYSTEM MANNER. TO EVALUATE THE LINEAR AG TECHNOLOGY WE AIM TO PERFORM AN ENGINEERING DESIGN ANALYSIS TO QUANTIFY THE REQUIRED SIZE AND MASS OF THE SYSTEM. WE ALSO AIM TO DESIGN A SCALE MODEL OF THE SYSTEM TO TEST ITS FEASIBILITY SUCH THAT IT CAN BE PROPERLY EVALUATED AS COUNTERMEASURE SYSTEM TO ENABLE LONG DURATION CREWED EXPLORATION MISSIONS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | Not listed | $27.9k | 10/16/17 | |
| Not listed | $27.9k | 10/16/17 |