This $350,000 National Science Foundation project grant supports research at the University of Virginia from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to advance understanding of the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, endothelial network formation, and extracellular matrix...
This $449,582 National Science Foundation project grant funds research at Virginia Polytechnic Institute and State University from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to understand the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, structural changes in capillary network formation...
This $1,017,602 National Science Foundation project grant supports research at North Carolina State University to develop microphysiological models for evaluating the role of age-dependent fibrinogen sialylation in wound healing. The three-year award under the NSF Engineering program (CFDA 47.041) will fund the creation of innovative tissue engineering techniques and microfluidic systems to study interactions between platelets and fibroblasts during wound healing. Researchers aim to better...
This $635,000 Project Grant awarded by the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation supports research to understand how mechanical boundary conditions influence tissue assembly and repair in 3D fibrous microtissues. The research aims to advance knowledge about the mechanisms by which mechanical forces regulate new tissue formation and organization, particularly as it relates to wound healing. The project will integrate in vitro experiments and...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $607,398 to Albany Medical College for research into the role of the epidermal integrin α3β1 in age-related declines in cutaneous wound healing. The overarching goal is to determine how waning integrin function contributes to reduced wound healing capabilities in the elderly. The 2-year...
This federal Project Grant award, provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), supports a research project at Temple University to investigate how microgravity and radiation exposure impact the function of engineered human adipose (fat) tissue. The $399,994 award, with a performance period from December 2024 to November 2027, will involve sending engineered adipose tissue samples to the International Space Station (ISS) for a 6-month study. The...
This $100,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program will support the development of an advanced wound care technology at Florida International University. Specifically, the university will create a bandage-integrated platform that provides feedback-mediated wound therapy to enable personalized care. The conformable platform is designed to non-invasively monitor multiple wound biomarkers in spatial detail and then apply targeted...
This $400,000 Project Grant award from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), under CFDA 47.041 Engineering program, will fund The Johns Hopkins University to develop engineered heart tissue chips for testing nanoparticle-based countermeasures against spaceflight-induced heart disease. The research aims to investigate whether nanoparticles designed to scavenge reactive oxygen species can prevent mitochondrial...
The National Science Foundation awarded a $399,685 project grant to the University of California Irvine under the Engineering program (CFDA 47.041) to develop innovative cartilage tissue engineering strategies utilizing the microgravity environment of the International Space Station. The objectives of the three-year award beginning September 1, 2022 include employing microgravity conditions to enhance key processes in earth-based cartilage tissue engineering such as redifferentiation of expanded...
This $311,770 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the mechanisms of tissue repair and wound healing in a Drosophila (fruit fly) in-vivo model system. The grant will fund research to: 1) understand how plasma membrane damage and cell rupture initiate different signaling pathways that promote wound stabilization and repair in epithelial tissues, and 2)...