Project Grant 2604905
- This SBIR Phase I project awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program seeks to develop a new class of gene therapies that can be delivered more safely, cost-effectively, and at scale for a wide range of serious genetic disorders. The project leverages short oligonucleotides conjugated with small molecules to induce proximity of endogenous epigenetic machinery to disease-relevant genes in a precise and reversible...
- Federal Grant Award Summary Neucore Bio, Inc. received a $304,951 Phase I Small Business Technology Transfer (STTR) award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) on June 15, 2025, with a completion date of May 31, 2026. The award funds development of fibroblast-derived engineered extracellular vesicles (EEVs) as nucleic acid therapeutic delivery systems for peripheral nervous system genetic disorders, with an initial focus...
- Federal Grant Award Summary The National Science Foundation (NSF) awarded Piezo Therapeutics, Inc. a $304,742 Project Grant under the Technology, Innovation, and Partnerships program (CFDA 47.084) for a Phase I Small Business Innovation Research (SBIR) project running from October 1, 2025 through September 30, 2026. The awardee will develop and validate a novel intradermal vaccine delivery platform that eliminates the need for lipid nanoparticles (LNPs) by utilizing electroporation technology....
- Federal Project Grant Summary Endura Therapeutics Inc. received a $303,445 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) on May 15, 2025, with completion targeted for January 31, 2026. The award funds development of a next-generation sequencing-based platform designed to discover and screen small molecule drugs that target RNA. The primary deliverables include establishing...
- The National Science Foundation (NSF) awarded a $274,966 Project Grant to Remedium Bio Inc., a for-profit organization, under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The grant supports the development of an adjustable gene therapy platform technology that will enable the use of genetic therapeutics beyond rare diseases, tackling large unmet clinical needs such as diabetes, osteoarthritis, and autoimmune diseases. The project aims to develop a dose-adjustable...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award for $275,000 will support the development of a plasmonic nanopore sensor device for quality control of adeno-associated viruses (AAVs) used in gene therapy. The proposed device will enable accurate characterization of AAV payload (single-stranded DNA, double-stranded DNA, or empty) at low, pre-scale-up concentrations to optimize formulations. The project aims to demonstrate the...
- Federal Grant Award Summary Amygo Solutions LLC received a $304,643 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation's Directorate for Technology, Innovation, and Partnerships (CFDA 47.084) effective July 1, 2026, through August 31, 2027. The company will develop and validate a novel blood test diagnostic for detecting transthyretin amyloidosis, a progressive protein misfolding disorder affecting approximately 500,000 individuals in the United...
- Federal Grant Award Summary Noara Therapeutics Corp. received a $305,000 Phase I Small Business Innovation Research (SBIR) grant from the National Science Foundation's Directorate for Technology, Innovation, and Partnerships (CFDA 47.084) effective July 1, 2026, through June 30, 2027. The award supports research and development activities focused on advancing RNA therapeutic design by establishing generalizable design principles that link molecular structure to biological performance. The...
- Federal Grant Award Summary Ivsonance Biomedical Inc. received a $305,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) effective October 1, 2025, through September 30, 2026. The awardee, based in Ithaca, New York, is developing a semi-automated acoustic tweezer system that uses modulated sound waves to provide contactless micromanipulation of delicate biological materials...
- Federal Project Grant Award Summary Synlibris, Inc. received a $304,957 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation's Directorate for Technology, Innovation, and Partnerships (CFDA 47.084) effective July 1, 2026, through June 30, 2027. The project develops a continuous evolution platform technology designed to accelerate the discovery of genetic solutions for high-yield protein biomanufacturing. The core innovation utilizes an orthogonal DNA...
The National Science Foundation's Directorate for Technology, Innovation, and Partnerships (TIP) awarded $305,000 to a small business under the SBIR Phase I program (CFDA 47.084) to develop a novel gene therapy platform that overcomes the cargo size limitations of adeno-associated virus (AAV) delivery systems. The project, initiated July 1, 2026 with completion targeted for December 31, 2027, focuses on designing and validating a scalable platform to deliver large therapeutic genes that are currently incompatible with AAV vectors due to their packaging capacity constraints. This innovation addresses a critical bottleneck in gene therapy development, enabling treatment of inherited genetic disorders caused by oversized genes that cannot be accommodated by existing AAV delivery technologies. The project targets inherited hearing disorders as an initial application, with potential to deliver first-in-class treatments for forms of deafness currently lacking effective therapeutic options. Beyond audiology, the platform technology has broader applicability to treating other genetic diseases caused by oversized genes, representing a significant advancement in genomic medicine. The awardee has proposed a commercial model utilizing outcome-based pricing strategies with projected revenue of $350 million from treating approximately 1,000 patients within three years of regulatory approval, while simultaneously strengthening U.S. biotechnology leadership in rare and ultra-rare disease treatment.Federal Project Grant Award Summary
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