Project Grant 2554683
- This three-year, $544,758 project grant from the National Science Foundation Division of Chemistry supports the development of new optical sensing methodologies to accelerate and broaden chiral compound analysis at Georgetown University. The university's Chemistry Department will introduce widely applicable small-molecule probes, novel molecular recognition strategies, artificial intelligence tools, and automated high-throughput experimentation technology. This will help overcome current...
- This $373,344 federal Project Grant award from the National Science Foundation's (NSF) Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), supports a collaborative research project led by Professors Julie Biteen of the University of Michigan and David Masiello of the University of Washington. The project aims to develop a multifunctional, high-sensitivity instrument to measure plasmon-enhanced chirality and enable the sensing of subtle, heterogeneous...
- The National Science Foundation Division of Chemistry awarded Purdue University $569,244 in project grant funding on September 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop ultrasensitive optical methods for probing molecular chirality at biological interfaces. Professor Garth Simpson's research group is developing fluorescence, scattering, and nonlinear optical spectroscopies capable of surface-specific chiral analysis with sub-monolayer sensitivity. The...
- This $126,656 Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), supports a collaborative research effort led by Professors Julie Biteen of the University of Michigan and David Masiello of the University of Washington. The goal is to develop a multifunctional, high-sensitivity instrument to measure plasmon-enhanced chirality and enable sensing of subtle, heterogeneous changes in chirality at the single-molecule...
- The National Science Foundation Division of Chemistry awarded $600,000 to The Regents of the University of Colorado on August 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop stereospecific methods for constructing sugar-based molecules. Dr. Maciej A. Walczak will lead research to create more reliable and predictable synthetic approaches for building complex carbohydrate structures with precise three-dimensional arrangements. The work targets applications in...
- The National Science Foundation Division of Chemistry awarded Massachusetts Institute of Technology $342,000 on July 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop design paradigms for magneto-optical materials through collaborative research on molecular and supramolecular helicity. Professor Timothy M. Swager at MIT and Professor Ori Gidron at the Hebrew University of Jerusalem are investigating molecules and assembled materials with helical electron...
- The National Science Foundation Division of Chemistry awarded the University of Colorado at Boulder $590,060 on July 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to support research on lanthanide chelation complexes and their solvent clusters using cryogenic ion spectroscopy. Professor Mathias Weber and his students will measure infrared spectra of lanthanide ion-chelator complexes and their clusters with solvent molecules in the gas phase using cryogenic ion...
- The National Science Foundation Division of Chemistry awarded the University of Maryland, College Park $499,479 on August 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop chemical principles for creating chiral inorganic nanomaterials and understanding how structural chirality controls charge, spin, and chemical reactivity. Professor Min Ouyang will establish a new class of all-inorganic chiral hybrid nanostructures by investigating how chirality can be...
- Federal Grant Award Summary The National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), awarded a $582,707 Project Grant to the University of California, Santa Barbara to Professor David Patterson for development of analytical tools capable of identifying the exact structure and chirality of single, trapped molecules. The research will develop a non-destructive, multi-step process that combines laser-cooled atoms, microwave pulse...
- The National Science Foundation Division of Chemistry awarded the University of Notre Dame $286,443 on August 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop electrochemical sensor platforms for detecting and distinguishing structurally similar small molecules in complex environments. The project, titled "Integrating Nanoconfined Interfaces and Aptamer Switches for Autonomous, Electrochemical Imaging of Chemical Analogs," will create...
The National Science Foundation Division of Chemistry awarded Georgetown University $592,706 on September 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop chiroptical sensing methodology for stereochemical analysis of organic molecules. Professor Christian Wolf's research group is developing optical sensing technology and innovative methods that enable rapid stereochemical analysis of challenging organic compounds—including biologically active compounds and disease biomarkers—without physical separation steps. The work will introduce chiroptical sensing methods capable of determining absolute configuration, enantiomeric and diastereomeric ratios, and concentration of compound classes including esters, amides, ethers, and tertiary amines. The project will demonstrate targeted sensing of multiple chirality centers in multifunctional molecules and separation-free analysis of multicompound mixtures using multi-modal optical sensing, Boolean-type molecular logic gates, and machine learning-informed chemometric data processing. New probe designs operating through metal coordination, dynamic covalent chemistry, irreversible bond formation, and halogen bonding will capture targets and transform molecular recognition via chirality. The research addresses bottlenecks in academic and industrial chiral compound development programs and will enable new applications using high-throughput screening and machine learning in currently impossible ways. Collaborations with industrial and academic partners will provide graduate, undergraduate, and high school students with educational and training opportunities alongside access to industrial testing facilities and compound libraries. Performance occurs at Georgetown University in Washington, DC, with a period of performance from September 1, 2026, through August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $592.7k | 8/13/26 |