Project Grant 2543298
- This Project Grant award, valued at $450,000.00, was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program. The award, effective from August 1, 2024 to July 31, 2027, supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University. The objective of this research program is to elucidate the fundamental mechanisms by which a...
- This Project Grant award for $450,000 was provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The funding supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University to investigate a group of four enzymes that utilize a single iron atom and molecular oxygen to catalyze diverse chemical reactions. The goal is to elucidate the...
- The National Science Foundation awarded a $249,988 Project Grant to the University of North Carolina at Greensboro under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new photocatalysts for green oxidation processes. Professor Shabnam Hematian and her research team will study catalytic processes using light and oxygen to generate value-added chemicals from hydrocarbons. Specifically, the team will develop oxo-bridged heterobinuclear systems containing different metal...
- The National Science Foundation Division of Chemistry awarded the University of California, Los Angeles $600,000 on July 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop selective iron-based chemical catalysts through computational and experimental methods. Professor Osvaldo Gutierrez and his research group at UCLA's Department of Chemistry and Biochemistry will use computational modeling, chemical synthesis, and robotics to accelerate development of...
- The National Science Foundation Division of Chemistry awarded the University of Georgia Research Foundation, Inc. $420,000 on September 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to investigate cytochrome P450 enzymes that catalyze aromatic nitration and crosslinking reactions during the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs). The research team will elucidate the catalytic pathways of CYP-catalyzed direct...
- The National Science Foundation Division of Chemistry awarded Brigham Young University $475,422 on August 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop fundamental theories about how atomic momentum controls pathways and product selectivity in transition metal-oxo chemical reactions. Professor Daniel Ess of the Department of Chemistry and Biochemistry is using quasi-classical ab initio molecular dynamics trajectories combined with quantum mechanical...
- The National Science Foundation Division of Chemistry awarded The Johns Hopkins University $650,000 on August 15, 2026, under the Mathematical and Physical Sciences program to develop new nonheme iron complexes for nitrogen oxide activation and electrocatalysis. Dr. David P. Goldberg and Dr. V. Sara Thoi will investigate iron-based chemical systems designed to convert nitrogen oxide pollutants (NOx) into ammonia through electrochemical processes inspired by natural iron-containing enzymes. The...
- The National Science Foundation Division of Chemistry awarded $591,929 to the University of Georgia Research Foundation, Inc. on August 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to fund research into low-oxidation-state main group chemistry as a replacement for transition metal species in industrial chemical manufacturing. Dr. Gregory H. Robinson and Dr. Yuzhong Wang will investigate the substitution of rare and expensive transition metals such as gold, silver,...
- Emory University was awarded a $450,000 project grant from the National Science Foundation Division of Chemistry to support research investigating the mechanisms of hydrogenase function. The three-year award, made under the Mathematical and Physical Sciences program (CFDA 47.049), will allow Emory researchers to advance understanding of major problems in the natural sciences through increasing knowledge of how the hydrogenase enzyme catalyzes reactions involving hydrogen. Work will be...
- This $575,000 project grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) supports research at Emory University to develop practical methods for conducting synthetic organic transformations using low catalyst loadings. The goal is to create highly efficient catalysts, such as rhodium and ruthenium-based catalysts, that can be used in extremely low amounts to enable over 100,000 reaction cycles while...
The National Science Foundation Division of Chemistry awarded Emory University $658,531 on August 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop and apply time-resolved X-ray methods for understanding iron-catalyzed oxidation mechanisms in biological systems. The research team will use photoinitiation methods combined with serial crystallography and X-ray spectroscopy to characterize ferryl and peroxo intermediates in mononuclear non-heme iron enzymes, generating molecular movies that correlate structural dynamics with metal-center changes during catalysis. The work focuses on representative iron(II) and 2-oxoglutarate-dependent oxygenases and aromatic amino acid hydroxylases, examining whether oxygen-oxygen bond cleavage and ferryl formation follow conserved geometric pathways or reflect catalytic-context-specific structural adaptations. Discoveries are intended to establish a framework for understanding biological oxidation chemistry with applications to biotechnology, sustainable catalysis, human health, and environmental remediation. The award funds research performed in Atlanta, Georgia, with a period of performance from the award date through July 31, 2031. The project includes public outreach through partnerships with Science ATL and curricular innovations in undergraduate physical chemistry education, alongside interdisciplinary research training opportunities.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $658.5k | 8/14/26 |