Project Grant 2532544
- This federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $200,138 to North Carolina State University to develop a wireless bioelectronic system for high-performance fentanyl monitoring in the brain of freely moving small animal models. The key goals are to: 1) engineer aptamers targeting fentanyl, a primary opioid associated with opioid use disorder (OUD); 2) develop an implantable nanoporous electrochemical aptamer-based (nanoeAB)...
- The National Science Foundation (NSF) Division of Electrical, Communications and Cyber Systems awarded a $399,541 Project Grant to the Trustees of Dartmouth College to develop a high-throughput, label-free, and portable sensor that can quantitatively detect multiple illicit drugs including opioids, cocaine, psychostimulants, and methadone in liquid samples such as biofluids. The project aims to create a silver or gold nanoparticle-decorated zinc oxide nanorod coated silica nanofiber matrix...
- This federal Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program provides $649,585 to Auburn University to develop an integrated and miniaturized opioid sensor system. The project aims to address the opioid crisis through innovative, cost-efficient, and portable opioid biosensors that can enable real-time, accurate detection and monitoring. The interdisciplinary team is working to deliver solutions for law...
- This Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) provides $450,000.00 to the University of Texas at Austin over the period of January 1, 2025 to December 31, 2027. The project aims to develop novel biosensing tools for therapeutic drug monitoring, specifically for the antipsychotic medication clozapine. The key products and services to be delivered include: Selection and optimization of DNA/RNA aptamers that bind strongly and...
- The National Institute on Drug Abuse (NIDA), under the Federal Grant Program titled "Drug Use and Addiction Research Programs" (CFDA 93.279), awarded a $305,369 Project Grant to Taesun, LLC, a for-profit, woman-owned limited liability company based in Salida, Colorado. The award aims to develop a comprehensive device that integrates fentanyl test strips with sample preparation features, providing a more convenient and discreet method for fentanyl testing in high-risk environments....
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to assess the impact of chronic, voluntary fentanyl intake on gene expression and neuronal activity in the brain. Specifically, the $139,927 award to the University of Washington will fund studies using single-cell RNA sequencing and whole-brain imaging in mice to investigate the molecular and circuit-level mechanisms underlying...
- This Project Grant award, valued at $495,950.00, was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) with a start date of September 1, 2025 and an expected completion date of August 31, 2028. The award was granted to The Washington University in St. Louis, Missouri to investigate the mechanisms by which the mu opioid receptor (MOR) signaling within the nucleus of the solitary tract (NTS) mediates fentanyl-induced cardiorespiratory...
- The National Science Foundation (NSF) awarded a three-year, $449,999 Project Grant under their Engineering program (CFDA 47.041) to the University of Cincinnati to develop an implantable biosensor platform that can continuously monitor various biomarkers in the body for over a year. The project aims to create a new class of long-lasting aptamer-based sensors protected by robust porous oxide coatings, which would enable the first practical implantable monitoring system for managing chronic...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) is supporting the development of a new nanopore sensing mechanism and approach for the ultrasensitive, label-free electrical detection of small biomolecules and bioactive molecules, such as ATP, hormones, and pharmaceutical drugs. The $442,106 award to Florida International University will fund research to overcome the challenges in detecting and analyzing small molecules under physiological...
- This federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $540,458 to Louisiana Tech University to develop an advanced implantable neural interface device. The goal is to create a transformative technology capable of simultaneously monitoring multiple brain signals, including both chemical and electrical, over extended periods. By integrating innovative materials and fabrication techniques, the device aims to enhance signal detection...
This federal Project Grant award for $358,371, provided by the National Science Foundation's Engineering program (CFDA 47.041), aims to develop a wireless bioelectronic system for high-performance fentanyl monitoring in the brains of freely moving small animal models. The key objectives are to: 1) isolate, characterize, and engineer aptamers targeting fentanyl; 2) develop an implantable nanoporous electrochemical aptamer-based (nanoeAB) fentanyl sensor and study a new surface coating to improve its in vivo longevity; and 3) establish and validate the wireless bioelectronic system for fentanyl monitoring in the brain. The project, awarded to the University of Connecticut, will also involve training high school and undergraduate students in experimental techniques, data analysis, and scientific writing, and incorporate new course modules into existing undergraduate and graduate programs. This work aims to provide urgently needed technologies to understand how opioids modulate brain function and behavior, with potential applications in therapeutic drug monitoring, immune response tracking, and chronic disease management.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/5/25 | ||
| Not listed | $358.4k | 8/5/25 |