Project Grant 2530334
- This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $500,000 in funding to The Regents of the University of Colorado to develop a suite of fluorescent RNA-based biosensors for monitoring metabolites in the methionine cycle of one-carbon metabolism in live cells. The project aims to create a "plug-and-play" toolkit of biosensors that can be used to study the dynamics and flux of central metabolites involved in regulating...
- This $475,670 CAREER Project Grant awarded by the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041) aims to develop a new method for tracking molecular changes in live tissue over time. The project will focus on creating a nanostructure-based system to continuously monitor cellular activity and interactions, which can help improve understanding of cellular behavior and advance medical treatments, particularly for complex...
- This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
- The National Science Foundation (NSF) awarded a $299,772 EAGER (Early-concept Grants for Exploratory Research) grant under the Biological Sciences program (CFDA 47.074) to Washington State University (WSU) to develop new molecular tools for identifying protein-protein interactions within specific cellular compartments in plant cells. The project, titled "TOOLS4CELLS: Bimolecular Proximity Tagging", aims to close the gap in existing methods by creating split enzyme versions that can map...
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
- The National Science Foundation (NSF) awarded a $300,000 Project Grant under its Biological Sciences program (CFDA 47.074) to the Georgia TECH Research Corporation for the "TOOLS4CELLS: EAGER: A MOLECULAR PURSUIT FOR THE ENGRAM: MICROFLUIDIC TEMPORAL TRANSCRIPTOMICS FOR SINGLE CELL LEARNING" project. This 2-year effort aims to develop innovative microfluidic tools and workflows to investigate the role of non-coding RNA in learning and memory storage in single-celled organisms. Key...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $449,999.00 to develop a new class of wireless, free-floating biosensors that integrate electronic and biological sensing elements. The goal is to enable in situ, real-time monitoring of microbial dynamics within industrial fermentation environments. The sensors combine engineered microbes that emit bioluminescent signals in response to cellular stress and metabolite levels, with...
- This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $590,000 Project Grant to the University of California Irvine (UC Irvine) on August 15, 2023 under the Biological Sciences program (CFDA 47.074). The goal of this 3-year research project is to develop novel strategies for real-time metabolite sensing and metabolite-induced enzyme localization that can contribute to fundamental cellular knowledge and improve the efficiency of synthetic biology...
- This Project Grant award from the National Science Foundation's (NSF) Engineering Program (CFDA 47.041) provides $2,999,724.00 to the University of Florida to develop versatile, portable, and sensitive biosensing devices that use living cells as biosensors. The project aims to overcome limitations of current detection methods for pathogens, toxins, and biological/chemical threats by harnessing fundamental physical principles underlying modern electronic devices. Key goals include broadening...
This Project Grant award of $350,000.00 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports the development of a new method for real-time measurement of endogenous biomolecules in live cells. The "TOOLS4CELLS" project at Tufts University aims to create a novel "turn-on biosensor" technology that can quantify changes in protein levels, such as beta-catenin, with much higher sensitivity and less background noise than existing methods. The new biosensors are expected to provide richer biological data and have a broader impact on the field by being simpler, more quantitative, and more cost-effective than current approaches. This project will leverage computational design, machine learning, and directed evolution to create prototype biosensors, with an initial focus on monitoring beta-catenin, a key regulator of cell growth and differentiation. The award period runs from August 1, 2025 to July 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $350.0k | 7/28/25 |