Project Grant 2529574
- This National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation Project Grant, awarded under CFDA Program 47.041 - Engineering, will provide $399,975 from September 1, 2023 to August 31, 2026 to Colorado State University to conduct research on the effects of microgravity and mechanical deconditioning on tissues. The research aims to investigate how mechanical unloading and microgravity trigger changes in cell nuclei and gene expression, and to develop...
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
- This $449,582 National Science Foundation project grant funds research at Virginia Polytechnic Institute and State University from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to understand the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, structural changes in capillary network formation...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $399,276.00 to the University of Puerto Rico's Research and Development Center Division, operating through the Chancellor Mayaguez Campus, to investigate how mechanical forces from growth substrate rigidity and microgravity affect the function of mesenchymal stem cells (MSCs) and their ability to stimulate or suppress the body's immune response. The project aims to identify signals...
- The National Science Foundation awarded a $399,685 project grant to the University of California Irvine under the Engineering program (CFDA 47.041) to develop innovative cartilage tissue engineering strategies utilizing the microgravity environment of the International Space Station. The objectives of the three-year award beginning September 1, 2022 include employing microgravity conditions to enhance key processes in earth-based cartilage tissue engineering such as redifferentiation of expanded...
- This federal Project Grant award, provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), supports a research project at Temple University to investigate how microgravity and radiation exposure impact the function of engineered human adipose (fat) tissue. The $399,994 award, with a performance period from December 2024 to November 2027, will involve sending engineered adipose tissue samples to the International Space Station (ISS) for a 6-month study. The...
- This $350,000 National Science Foundation project grant supports research at the University of Virginia from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to advance understanding of the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, endothelial network formation, and extracellular matrix...
- This $600,000 Project Grant awarded by the National Science Foundation (NSF) under CFDA Program 47.041 Engineering supports research to leverage light-matter interactions and the low-gravity space environment to develop new functional sensors. The project, titled "BRITE PIVOT: Leveraging Light-Matter Interactions to Create New Functional Sensors in Low-Gravity Space Environment," aims to investigate the effects of microgravity on the processing of nanocomposites and utilize this...
- This federal Project Grant award, funded by the National Science Foundation's Engineering program (CFDA 47.041), supports research to grow three-dimensional cancer-myeloid organoids on the International Space Station (ISS) in order to better mimic brain tumor formation and study interactions between cancer and immune cells. The $400,000 award, with a project period from September 2024 to August 2027, will first generate "flight-ready" organoid seeds from various cancer and immune...
- This $420,000 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports collaborative research on the effects of microgravity conditions on crystal growth and particle self-assembly during directional solidification of solutions. The research aims to reveal the subtle forces involved in these processes when gravity is removed, and compare the structural features obtained in microgravity versus on Earth. The research will integrate experimental...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) is focused on elucidating the role of integrin mechanotransduction in cellular responses to microgravity conditions. The $400,000 award to Emory University, with a performance period from November 1, 2025 to October 31, 2028, will support the development and deployment of molecular tension fluorescence microscopy probes to quantify integrin forces under microgravity aboard the International Space Station (ISS). This research aims to reveal the fundamental mechanisms by which cells sense and respond to the tiny gravitational forces experienced in microgravity environments. Success in this project will enable precise measurements of cell forces and signaling consequences in microgravity, which could lead to a better understanding of how cells adapt to altered gravity conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $400.0k | 8/28/25 |