Project Grant 2529546
- This National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation Project Grant, awarded under CFDA Program 47.041 - Engineering, will provide $399,975 from September 1, 2023 to August 31, 2026 to Colorado State University to conduct research on the effects of microgravity and mechanical deconditioning on tissues. The research aims to investigate how mechanical unloading and microgravity trigger changes in cell nuclei and gene expression, and to develop...
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) is focused on elucidating the role of integrin mechanotransduction in cellular responses to microgravity conditions. The $400,000 award to Emory University, with a performance period from November 1, 2025 to October 31, 2028, will support the development and deployment of molecular tension fluorescence microscopy probes to quantify integrin forces under microgravity aboard the International...
- This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $240,146 to the University of Alabama to conduct collaborative research on the effects of cellular deformation on the proliferation and motility of single cells. The research aims to engineer specialized microfluidic devices that simulate the tight spaces cells encounter in the human body, enabling the observation of how physical stress impacts cell division, movement, and...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will provide $646,451.00 to The Regents of the University of Colorado over a 5-year period from June 1, 2025 to May 31, 2030. The project, titled "CAREER: Defining How Extracellular Matrix Mechanics Regulate Neutrophil Function", will conduct research to understand how a tissue's mechanical properties influence the function of neutrophils, a key immune cell type. The research aims to...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $400,000.00 to the University of Connecticut to develop "immunomodulating cartilage tissue constructs" with applications for both space and terrestrial environments. The project aims to engineer advanced cartilage tissue that can survive and function in challenging conditions such as inflammation or low-gravity. It will leverage nanotechnology to create "smart"...
- This $382,124 federal Project Grant award, made by the National Science Foundation's Engineering program (CFDA 47.041), aims to advance tissue engineering and in-space cell technologies for regenerative medicine applications. The award will fund a collaborative effort between Micro-Grx, Inc., the University of Florida, Ronawk, and Redwire to develop three-dimensional "bio-block" tissue models that mimic the vascularization of heart and skin cells. These bio-block organoids will be used...
- This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research to elucidate how the fluid-like properties of tissue extracellular matrices influence cell fate decisions in response to growth factors. The $480,237 grant, awarded to The Pennsylvania State University (Penn State) on August 1, 2024, will fund the development and characterization of viscoelastic materials to study the impact of matrix viscous dissipation on cell...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $250,120 Project Grant to Clemson University to conduct collaborative research on the effect of cellular deformation on the proliferation and motility of single cells. The goal is to engineer specialized microfluidic devices to study how physical stresses experienced by cells in the human body, such as when they move and squeeze through tight spaces, impact their ability to divide and migrate. This research aims to...
- This $995,498 National Science Foundation project grant supports research at the University of California, Los Angeles to advance knowledge of cellular mechanobiology and translate findings for sustainable protein production. Funded through the NSF's Engineering program (CFDA 47.041), the research aims to understand how cells sense and respond to mechanical stimuli by building a systems-level understanding of the "mechanome." Specific goals include investigating predicted mechanical...
This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $399,276.00 to the University of Puerto Rico's Research and Development Center Division, operating through the Chancellor Mayaguez Campus, to investigate how mechanical forces from growth substrate rigidity and microgravity affect the function of mesenchymal stem cells (MSCs) and their ability to stimulate or suppress the body's immune response. The project aims to identify signals altered by physical cues and potential medications that could support MSC function, with the goal of informing the design of cell culture systems for disease modeling and production of high-quality MSCs for tissue regeneration therapies. This award, with a performance period from December 1, 2025 to November 30, 2028, will also support workforce development by training students in biomaterial engineering and cell biology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $399.3k | 8/15/25 |