Project Grant 2527295
- This Project Grant award of $100,000 from the National Science Foundation (CFDA 47.049 - Mathematical and Physical Sciences) will support a collaborative research project at Yale University focused on developing an Artificial Intelligence (AI)-enhanced multiphysics and multiscale framework for mechanistic modeling of erythrophagocytosis. The project aims to investigate how biochemical signaling pathways and red blood cell biomechanics are intertwined in dictating the erythrophagocytosis process,...
- This federal Project Grant award of $100,000.00 from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports the development of an Artificial Intelligence (AI)-enhanced multiphysics and multiscale framework to investigate the mechanistic modeling of erythrophagocytosis - the complex process by which phagocytic cells recognize, engulf, and digest aged or diseased red blood cells. The project aims to quantify the impact of biochemical signaling...
- This Project Grant award of $275,956.00 from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program supports the development of an engineered cyber-physical system that combines advanced biological models with state-of-the-art artificial intelligence methods for predictive, automated screening of anti-cancer drugs and optimizing their dosing. The goal is to realize a precision medicine paradigm that can improve health outcomes and reduce treatment...
- This $728,539 federal Project Grant award to Emory University, funded by the National Science Foundation's (NSF) Division of Physics, supports research to "bridge the gap between particle-based and continuum hydrodynamic descriptions of dusty plasma" using artificial intelligence (AI) and machine learning (ML) techniques. The project aims to derive new physical and statistical laws governing the complex motion of dust particles in plasma, which are common throughout the universe. The...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) provides $292,686 to Brandeis University to develop coarse-grained models and numerical methods for simulating the behavior of fluids containing suspended elastic objects, such as red blood cells and platelets, in confined geometries. The goal is to accurately capture the effects of boundary interactions and accelerate simulations of these phenomena, which are relevant for...
- This $350,000 federal Project Grant was awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program. The goal of the research is to develop accurate mathematical models and computer simulations for studying non-equilibrium systems with memory effects, such as those found in biosystems, plasma evolution, and solid-state nanostructures. The Principal Investigator will focus on analytical and numerical approaches to statistical transport...
- This $414,390 National Science Foundation project grant supports research at Eastern Michigan University to advance understanding of autophagy, a cellular recycling and protection process. Funded under the NSF Biological Sciences program (CFDA 47.074), the three-year award beginning in February 2023 will investigate the molecular mechanisms that drive formation of the autophagosome, a vesicle that degrades cellular cargo. Researchers will study proteins involved in conjugating the ATG8 protein...
- This $809,743 Project Grant award from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) will develop an artificial intelligence (AI) and machine learning (ML)-driven platform to accelerate the discovery and optimization of small molecules for combating antibiotic resistance, biofilms, and aflatoxin contamination. The collaborative effort between South Dakota State University (lead), South Dakota Mines, and the University of Nevada, Las Vegas will pursue three...
- This $116,105 federal Project Grant award, provided by the National Science Foundation's Division of Mathematical Sciences under CFDA 47.049 Mathematical and Physical Sciences program, supports a collaborative research project between the University of California-San Diego, Xavier University of Louisiana, and the University of California-Irvine. The project aims to develop mathematical models that bridge the evolutionary dynamics of mutant cell growth in the blood between mouse and human...
- The National Science Foundation (NSF) is awarding a $360,000 Project Grant under the Engineering program (CFDA 47.041) to the University of Alabama. The grant, with a period of performance from September 1, 2025 to August 31, 2028, will support the development of a 3D engineered model that incorporates innate immune cells (macrophages and microglia) to study drug resistance in brain metastatic breast cancer (BMBC). This biomimetic model will be used to investigate how microglia and macrophages...
This Project Grant award, provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), supports the development of an AI-enhanced multiphysics and multiscale framework to investigate the complex process of erythrophagocytosis - the recognition, engulfment, and digestion of aged or diseased red blood cells by phagocytic cells. The $100,000 award to the University of Georgia aims to validate the hypothesis that erythrophagocytosis is governed by both biochemical signaling pathways and the biomechanics of red blood cells. The project will apply the AI-enhanced framework to quantify the impact of these factors on macrophage-mediated red blood cell engulfment, with potential applications in understanding the pathogenesis of hemolytic anemia and cancer immunotherapy. The research outcomes will also be integrated into three university courses and involve the recruitment of undergraduate and high school students.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $100.0k | 8/8/25 |