This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award totaling $754,903 to Yale University provides funding for a collaborative research project between investigators in the United States and Germany. The research aims to use advanced microscopy techniques to map the spatial distribution and organization of a critical complex involved in immune system recognition within the endoplasmic reticulum (ER) of cells. By examining how ER morphology influences the function of this complex, the project seeks to gain broader insights into the role of ER architecture in supporting essential cellular processes. Key activities under this 3-year award include training graduate students and postdoctoral researchers, as well as providing hands-on learning opportunities for local high school students through outreach initiatives. The results of this work are expected to deepen the understanding of antigen presentation and contribute to the field of ER research.
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