Project Grant 2515288
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $100,000 Project Grant to Boise State University to conduct planning activities related to "Organoid-Directed Muscle Control." The grant aims to broaden participation in this research area by engaging national leaders, forming vertically integrated research teams, and developing an understanding of the ethical, legal, and social implications of biocomputing through engineered organoid intelligence. Key...
- This $200,000 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to establish a closed-loop hybrid intelligence (HI) framework that connects biological and physical computing systems. The research project will co-design high-resolution optoelectronic neuromodulation and neuromorphic hardware to enable closed-loop interfacing with cultured neurons and organoids. The HI system will showcase the power of optogenetic-neuromorphic co-design for...
- This $2,000,000 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support a project at Lehigh University to explore the use of layered biological neural networks for processing dynamic visual information. The project aims to develop functional and structural networks in multilayer neuronal organoids that can mimic the visual pathway in the brain, with the goal of enabling improved object identification in video. Ethical, legal, and social...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will provide $1,958,603.00 to the University of California, Santa Cruz (UCSC) to explore whether lab-grown human brain tissues, known as brain organoids, can perform computations similar to artificial intelligence (AI) systems. The award, titled "EFRI BEGIN OI: REINFORCEMENT LEARNING FOR SCALABLE BIOCOMPUTING," will fund the development of tools that allow these brain organoids to...
- This $1,998,582 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support the development of biotechnology to grow cellular brain organoids capable of replicating network and activity observed in the human brain. The research team at The University of Texas at San Antonio (UTSA) will integrate these brain organoids into an engineered system and program them to solve increasingly complex associative problems, evaluating how this bioengineering...
- The National Science Foundation (NSF) awarded a $2,000,000 Project Grant under the Engineering program (CFDA 47.041) to the University of California, Irvine to develop and assess the feasibility of 3D biological neural networks (3DNNs) for intelligent biomedical motor control systems. The objectives are to establish methods to fabricate robust, reliable, and reproducible 3DNNs, and to develop core principles to program them with intelligent behavior. This research aims to demonstrate...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded The Johns Hopkins University a $1,999,508.00 Project Grant to advance the field of Organoid Intelligence (OI). The project seeks to incorporate reward-based learning mechanisms into lab-grown brain organoids to enable more complex and adaptive behaviors, with the goal of creating computing devices that use substantially less energy than today's AI systems. The research team will connect the brain organoids to...
- The National Science Foundation awarded Boise State University a $199,999 project grant under the Engineering program (CFDA 47.041) to develop microscale neural implants for closed-loop neuromodulation from March 2022 through February 2024. The university will advance bioelectronic medicine miniaturization to enable simultaneous neural sensing and stimulation for personalized closed-loop therapy. Key activities include developing a cross-domain simulation framework to optimize microscale...
- This $400,000 Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) supports the development of a new hardware system designed to meet the increasing computational demands for sophisticated multi-scale brain models. The project aims to bridge the timescales between cognitive phenomena and the underlying neuronal processes, enabling more detailed computer simulations to advance fundamental neuroscience research and the translation of biological...
- This $260,609 Project Grant from the National Science Foundation Division of Electrical, Communications and Cyber Systems will support the development of multi-channel, sub-microliter implants for selective neuromodulation at Boise State University from September 1, 2023 through August 31, 2028. The grant is jointly funded through NSF's Engineering Directorate and Established Program to Stimulate Competitive Research, both of which aim to advance innovation in engineering research. Under this...
This $2,000,000 Project Grant awarded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support a research project at Boise State University to explore how brain-like structures grown in the lab, known as brain organoids, can be trained to control muscle contractions. The goal is to harness the power of biological neural networks to create low-power, adaptable computing systems that could have applications in healthcare, robotics, and national defense. The research team will develop a biocomputing platform that interfaces human-derived neuronal organoids with ex vivo muscle tissue, using a high-density, multi-channel stimulation system to map organoid outputs to muscle activation patterns. The project will also develop complementary digital twins and machine learning models to simulate and assess the performance, efficiency, and scalability of this organoid-directed muscle control approach compared to synthetic algorithms. If successful, this work could lead to more sustainable computing solutions. The award period is from September 1, 2025 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.0m | 8/20/25 |