Project Grant 2504059
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the University of California Irvine $343,554 on May 1, 2026, to develop a directed evolution workflow for surface-displayed enzymes on bacterial spores under the Engineering assistance program (CFDA 47.041). The project will identify enzymes that function under harsh chemical processing conditions—high temperatures, extreme pH values, and organic solvents—by leveraging the...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences and the Division of Chemical, Bioengineering, Environmental and Transport Systems awarded a $240,000 Project Grant to the University of California Irvine (UC Irvine) under the NSF Biological Sciences program (CFDA 47.074). The grant supports collaborative research to develop unnatural cofactors that can be deployed as stronger-than-nature thermodynamic driving forces in biomanufacturing processes. This is...
- The National Science Foundation Division of Chemistry awarded the University of California, Los Angeles $750,000 on July 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop catalytic methods using earth-abundant metals and ligand-based cooperativity to activate carbon-hydrogen bonds in chemical synthesis. Dr. Matthew Nava will lead research to replace rare and expensive noble metals in essential chemical reactions with common, inexpensive main-group elements...
- The National Science Foundation Division of Chemistry awarded the University of California, Los Angeles $400,000 on August 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop and apply artificial intelligence to accelerate catalyst discovery in ethylene copolymerization and ethylene-CO2 coupling reactions. Professor Paula Diaconescu of the Department of Chemistry and Biochemistry leads the project, which uses machine learning and network science approaches to...
- The University of California Irvine received a $339,247 project grant award from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems on July 15, 2021 to fund research titled "Understanding and Engineering the Nucleation of Enzyme Metal-Organic Frameworks." The project aims to improve understanding of how enzymes interact with and are incorporated into metal-organic frameworks to catalyze chemical reactions. The research is...
- This Project Grant award of $900,000.00 from the National Science Foundation's (NSF) Division of Chemistry, under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), supports research by Professors Houk and Tang of the University of California, Los Angeles (UCLA) to study the development of a new class of enzymes called "pericyclases." The researchers aim to characterize the mechanisms by which these enzymes catalyze natural product biosynthetic reactions,...
- The National Institute of General Medical Sciences awarded the University of California, Los Angeles $420,981 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop engineered enzymatic catalysts for asymmetric hydrogen atom transfer reactions in synthetic chemistry. The research integrates organic chemistry, protein engineering, bioinorganic chemistry, and computational modeling to design and evolve biocatalysts that enable...
- The University of California, Los Angeles (UCLA) was awarded a $502,130 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the NSF Engineering program (CFDA 47.041). The grant will fund research from September 2021 through August 2024 to model electrocatalysts under operating conditions and study their surface restructuring and catalytic activity. The project aligns with the NSF Engineering program's goals...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded Tulane University $439,707 on November 1, 2026, under the Engineering program (CFDA 47.041) to map structural coupling networks that control enzyme catalysis and improve understanding of enzyme function for industrial applications. The project uses combined experimental and computational approaches to uncover functional relationships between enzyme structure and catalytic...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded Ball State University $392,649 on May 1, 2026, to develop improved aromatic-metabolizing enzymes through enzyme engineering strategies under the Engineering program (CFDA 47.041). The project will engineer three families of aromatic-metabolizing enzymes—extradiol dioxygenases, aromatic peroxygenases, and ferulic acid decarboxylases—to react more efficiently with molecules containing...
The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the University of California, Los Angeles $625,000 on September 1, 2026, for mining and engineering new biocatalysts for sustainable chemoenzymatic synthesis under the Engineering program (CFDA 47.041). The project will discover and characterize ATP-grasp and amide bond synthetase enzymes from fungi that catalyze carbon-nitrogen bond formation under mild reaction conditions. These standalone enzymes can efficiently form amide bonds through carboxylate activation and amidation without requiring multi-enzyme cascades, addressing environmental and efficiency gains of enzyme-based catalysis over conventional chemical processes. The work will develop computational and machine learning methods to explore enzyme diversity and generate insights into sequence-structural-functional relationships, with primary focus on distinguishing amide bond-forming enzymes from other ATP-dependent enzymes that do not form amide bonds. The resulting biotechnology could advance biomanufacturing of high-value medicines and advanced materials. UCLA's Office of Research Administration will perform the work at the Los Angeles, California campus through August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $625.0k | 8/13/26 |