This National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award to Carnegie Mellon University (CMU) provides $500,000 in funding from July 1, 2024 to June 30, 2027 to develop a new computational framework for predicting neuron growth and transport regulation in biological neural circuits (BNCs). The project aims to advance knowledge of the fundamental mechanisms of neural growth, material transport regulation, and circuit dynamics through three specific objectives: (1)...
This Project Grant award, titled "CAREER: UNIFYING NEUROSCIENCE AND BIOMECHANICS PARADIGMS FOR MODELING BRAIN AND MUSCLE RESPONSES TO MECHANICAL IMPACTS", was provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041). The $399,269 award, effective from October 1, 2024 to October 31, 2028, will support the University of Florida in developing a breakthrough computational framework, called BMI-FRAME, to study the relationship between brain neuronal dynamics and...
This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $124,588 to the University of Notre Dame to investigate how physical forces, specifically axonal tension or the pulling forces exerted by nerve fibers, shape the complex folded structure of the human brain. The primary hypothesis is that axonal tension helps determine the placement of cortical folds and ensures efficient axonal connections. The research aims to develop advanced...
This $402,623 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports a 3-year REU (Research Experiences for Undergraduates) site focused on injury science research at The Children's Hospital of Philadelphia (CHOP). The program provides 10-week summer internships for undergraduate students to engage in mentored research projects aimed at addressing leading injury risks to children, such as sports-related injuries, traffic crashes, and violence. Key...
The National Science Foundation (NSF) awarded The Johns Hopkins University a 3-year, $274,297 Project Grant under the Engineering program (CFDA 47.041) to conduct collaborative research on the extreme mechanics of the human brain. The research aims to generate insights into how the living human brain responds to large and rapid loading, which is critical for developing models to predict traumatic brain injury and designing safer protective equipment. The project will combine high-rate mechanical...
This National Science Foundation Project Grant, awarded under the Engineering program (CFDA 47.041), provides $206,132 to Louisiana State University to conduct fundamental research on the high strain rate mechanics of the human brain. The research aims to develop advanced computational models and experimental techniques to better understand the complex mechanical behavior of the living human brain under extreme loading conditions, such as those encountered during traumatic brain injuries. The...
This $476,886 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research at Boston University to develop computational models for predicting the spatiotemporal distribution of growth factors in tissue engineering scaffolds. The goal is to optimize scaffold designs to achieve optimal growth factor exposure profiles that improve tissue regeneration outcomes, particularly for cartilage repair. The research utilizes reaction-diffusion...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support research to study how astrocytes, a critical cell type in the brain, respond to mechanical forces and strain associated with traumatic brain injury (TBI). The $705,806 award to Tufts University will fund the development of controlled 3D brain-like cell culture environments and ex vivo brain cultures to quantify astrocytes' acute and chronic responses to mechanical perturbation...
This $549,195 federal Project Grant award from the National Science Foundation's Engineering (CFDA 47.041) program will support the development of a minimally invasive, wireless implantable optical sensor to measure touch and tactile forces for neuroprosthetic applications. The device utilizes photoplethysmography to indirectly infer tactile forces from changes in skin blood volume, providing sensory feedback to help restore hand function for individuals with paralysis from stroke or spinal cord...
This Project Grant award from the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation provides $390,593 to Syracuse University for research on the mechanoregulation of amnion patterning through activation of bone morphogenetic protein signaling. The 3-year project aims to study amnion development using a stem cell-derived human development model, with the goal of advancing knowledge in early human development and enabling the rational design of 3D stem...