Project Grant 2400304

This National Science Foundation Project Grant award to The Ohio State University provides $595,000 from the Mathematical and Physical Sciences program (CFDA 47.049) to support the development of new catalytic strategies for the synthesis of cyclopropane compounds. Professor David Nagib and his research team will investigate methods to access cyclopropanes, a valuable motif in bioactive small molecules, using more sustainable and scalable approaches compared to current techniques that rely on unstable and specialized reagents. The research aims to enable improved and more affordable access to new molecules with broad applications in medicinal, materials, and agricultural chemistry. The project also provides training opportunities for graduate and undergraduate students, as well as outreach activities to inspire future scientists. No subawards are planned under this grant, which runs from May 2024 through April 2027.