This $575,000 Project Grant award from the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Berkeley will support Professor Thomas Maimone's research on developing new synthetic strategies for constructing complex, nitrogen-containing molecules. The work aims to identify transformations that can efficiently produce unique target molecules with potential applications in pharmaceuticals, agrochemicals, and materials. The...
This $306,532 federal Project Grant award from the National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will fund research at Yale University to investigate the role of molecular motions in the allosteric activation of the enzyme imidazole glycerol phosphate synthase. The project will utilize advanced field cycling nuclear magnetic resonance spectroscopy techniques, coupled with computational modeling, to gain unprecedented insights into the timescales and...
This Project Grant from the National Science Foundation Division of Chemistry provides $500,000 to New York University from August 1, 2021 through July 31, 2024 to support research titled "Towards a Greener Approach for Chemical Synthesis of Peptides." The award is part of the Mathematical and Physical Sciences program (CFDA 47.049), which aims to promote progress in these scientific fields and strengthen the national scientific enterprise through increasing knowledge and enhancing...
Yale University was awarded a $1,050,000 Project Grant from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) to conduct research probing the origins of intrinsic chiroptical response and the roles of extrinsic perturbations. The research will combine experimental measurements and theoretical analyses to study how atomic motions and surrounding solvent affect the chiroptical properties of molecules. Discoveries could have...
This $575,000 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research at Emory University to develop new synthetic methods and enabling strategies for the production of Ribosomally Synthesized Post-Translationally Modified Peptides (RiPPs). The goal is to create a universal catalytic platform to enable the synthesis of diverse RiPP natural products, which have shown promise as drug candidates but face...
This $284,861 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), supports research at Purdue University developing new carbonylation methodologies for synthesizing complex chemical structures with medicinal applications. Professor Mingji Dai and his research team are investigating palladium-catalyzed reactions incorporating carbon monoxide to rapidly increase molecular complexity in targeted natural...
This three-year, $1.2 million Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), supports the development of an integrated protocol for the computer-controlled synthesis and recursive optimization of macrocyclic oligourethanes as non-natural analogues of peptides for selective hydrolysis of nerve agent surrogates. Professor Eric V. Anslyn of the University of Texas at Austin will develop methods for...
The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded Yale University $326,083 under Project Grant NSF-DFG CHEM: PHOTOCATALYTIC ORGANIC SYNTHESIS BY HIGH-EFFICIENCY PLANAR SEMICONDUCTORS. The award period runs from August 15, 2021 through July 31, 2024. The funding supports research into photocatalytic organic synthesis using high-efficiency planar semiconductors, as part of the NSF Directorate for Engineering's Engineering program...
The National Science Foundation (NSF) awarded a $575,000 project grant under its Mathematical and Physical Sciences (MPS) program to the University of Wisconsin-Madison to study the use of light in organic synthesis. Under this 3-year award effective July 1, 2024, Professor Tehshik Yoon and his team will design novel photocatalysts that can interact directly with small molecules to control how they react and form more complex products. The research aims to transform discovery in pharmaceutical...
The National Science Foundation Division of Chemistry awarded a $1,050,000 Project Grant to the Scripps Research Institute under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support research exploring attached-ring cross-coupling chemistry and its applications. Over a three-year period from August 1, 2022 to July 31, 2025, Professor Ryan Shenvi of Scripps Research Institute will develop new non-precious metal reagents and methods for concise syntheses of...