Project Grant 2452699
- The Colorado School of Mines received a three-year, $455,655 Project Grant from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049). The grant funds research from September 2021 through August 2024 to elucidate mechanisms of perfluoroalkyl substance degradation in the environment through a coupled computational and experimental approach. The Mathematical and Physical Sciences program aims to advance scientific knowledge and...
- This federal Project Grant award, totaling $550,000 and awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049), supports research led by Professors Timothy Strathmann and Shubham Vyas at the Colorado School of Mines. The project aims to advance a photochemical technology for destroying per- and polyfluoroalkyl substances (PFAS), which are persistent contaminants in drinking water. The research focuses on understanding the underlying...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $150,000 to Claremont McKenna College to develop enzymatic pathways that can break carbon-fluorine bonds in perfluorinated carboxylic acids (PFAS). PFAS are a group of harmful chemicals that are costly and difficult to remove from the environment due to their stable carbon-fluorine bonds. The project aims to engineer specialized enzymes that can degrade these bonds, which could unlock...
- This Project Grant award, funded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), supports collaborative research aimed at discovering enzymatic pathways to break carbon-fluorine bonds in perfluorinated carboxylic acids (PFAS). PFAS are a group of persistent chemicals that are costly to remove from the environment. The $350,000 project, awarded on November 1, 2025 with an ultimate completion date of October 31, 2028, will take a new approach toward remediating PFAS...
- This $208,879 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research between Marquette University and the Colorado School of Mines to gain molecular-level insights into the catalytic mechanism of nitrile hydratase enzymes. Professors Bennett, Fiedler, and Holz will employ kinetic, spectroscopic, biochemical, computational, and X-ray crystallographic methods to detect intermediates, test competing mechanistic...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences Program (CFDA 47.049) provides $525,000 to East Carolina University (ECU) to study the functional and structural properties of enzymes involved in persulfide degradation. Specifically, Professor Holly Ellis and her research team at ECU will examine the catalytic mechanism and structural features of a mercaptopropionate dioxygenase (MDO) and a sulfurtransferase (ST) enzyme system that is critical...
- The National Science Foundation (NSF) awarded a $386,199 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the New Jersey Institute of Technology (NJIT) to develop a novel in-situ high-resolution mass spectrometry (HRMS) approach to detect short-lived degradation intermediates generated from the thermal or electrochemical degradation of per- and poly-fluoroalkyl substances (PFAS). The project, led by Professor Hao Chen, aims to better understand PFAS degradation...
- This Project Grant award for $450,000 was provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The funding supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University to investigate a group of four enzymes that utilize a single iron atom and molecular oxygen to catalyze diverse chemical reactions. The goal is to elucidate the...
- The National Science Foundation awarded a $214,427 Project Grant to the University of Vermont and State Agricultural College under the Engineering program (CFDA 47.041) to support collaborative research on microbial chain-elongation mediated dehalogenation and carbon transformation of chlorinated solvents from September 1, 2022 to August 31, 2025. The research aims to investigate using microbial chain elongation to produce the hydrogen required for Dehalococcoides mccartyi bacteria to reduce and...
- This Project Grant award from the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program provides $392,881 to Lehigh University to investigate the chemical and biological contributors to the biodegradation of water-soluble polymers. The research aims to develop a systematic understanding of how interactions between water-soluble cellulose derivatives and bacterial strains impact polymer biodegradation processes. Key focus areas include initial...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $555,000 to the Colorado School of Mines to investigate the enzymatic biodegradation of the fungicide chlorothalonil and the herbicide atrazine. The project aims to gain molecular-level insights into two zinc-dependent hydrolytic dehalogenase enzymes that degrade these halogenated aromatic compounds to less-toxic forms. The research will examine the catalytic mechanisms of the dehalogenase enzymes using an interdisciplinary approach including kinetics, spectroscopic, biochemical, computational, and X-ray analysis methods, as well as biomaterial synthesis. The project seeks to address key questions around the allosteric and structural influences on enzyme activity, the potential to use the enzymes in biomaterials for contaminant degradation, and whether the enzymes can dehalogenate related fluorinated and brominated substrates. The award period runs from September 1, 2025 through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $555.0k | 8/22/25 |