Project Grant 2449641
- The National Science Foundation (NSF) Division of Chemistry has awarded a $180,000 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to support a collaborative research project titled "INTERROGATING CATALYTIC EFFICIENCY THROUGH KINETIC, STRUCTURAL AND SMALL-MOLECULE GUIDED INVESTIGATION OF L-DOPA 2,3-DIOXYGENASES." The grant, with an award date of August 1, 2025 and an ultimate completion date of July 31, 2028, will fund a joint investigation by...
- The National Science Foundation (NSF), through its Mathematical and Physical Sciences (CFDA 47.049) program, awarded a $151,966 Project Grant to Randolph-Macon College. This grant, titled "LEAPS-MPS: EXPANDING ASYMMETRIC CATALYSIS WITH THIAMINE-DEPENDENT ENZYMES," will fund a research project led by Professor Reynolds and his students to explore the use of thiamine-dependent enzymes for the stereoselective formation of β-substituted ketones. The key objectives of this project are to:...
- This three-year Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems will support the development of new green-chemical catalysts based on Rieske dioxygenase scaffolds through directed evolution at Ball State University. Totaling $366,434, the award aims to evolve previously uncharacterized dioxygenases found in soil bacteria to expand their substrate ranges for valuable applications in organic synthesis and...
- This two-year, $249,840 Project Grant from the National Science Foundation's Mathematical and Physical Sciences Directorate will fund research into the contributions of adrenodoxin to cytochrome P450 catalysis, as well as related student support activities. Professor Michael Reddish of Appalachian State University will investigate how ferredoxin proteins enable cytochrome P450 enzymes to catalyze various chemical reactions important in nature and industrial processes. The research aims to...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) to the University of California, Berkeley provides $780,000 in funding to investigate the molecular mechanisms of oxygen-dependent enzymes and develop synthetic mimics. The key objectives are to study a class of oxygen-dependent decarboxylase enzymes that utilize iron, manganese, or mixed metal active sites. This research aims to elucidate the critical oxygen-activated...
- This $447,000 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), will support research at Haverford College from December 2022 through February 2026. The research team, led by Dr. Louise Charkoudian, will investigate type II polyketide biosynthetic enzyme assemblies across bacterial species to leverage their capabilities for sustainable chemical production. Undergraduate students will gain research...
- The National Science Foundation's (NSF) Mathematical and Physical Sciences program awarded a $249,982 Project Grant to Professor Steven Diver of the University at Buffalo, State University of New York, to study new bimacrocyclic catalysts for size-selective reactions catalyzed by earth abundant metals such as manganese, cobalt, nickel, and copper. The key objective is the design and modular synthesis of multidentate ligands with adjustable macrocyclic size to create or enhance...
- This federal Project Grant award of $600,000.00 was provided by the National Science Foundation (NSF) Division of Chemistry through the Mathematical and Physical Sciences Program (CFDA 47.049). The award will support a project led by Professor Diao of New York University (NYU) to study the design of new bidentate chiral nitrogen-based ligands for use in asymmetric catalysis. This research aims to develop more efficient and environmentally-friendly methods for synthesizing small molecule...
- Through a $575,000 National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) award, Cornell University will investigate ways of utilizing more abundant 1st row transition metals as alternatives to expensive precious metals commonly used in catalytic chemistry. The primary objective is to develop methods for modifying 1st row transition metal compounds with ligands to provide the chemical reactivity and covalency typically associated with 2nd and 3rd row transition...
- The National Science Foundation (NSF) Chemical Catalysis program awarded a $560,760 project grant to the University of North Carolina at Chapel Hill (UNC-CH) to study dearomatization reactions catalyzed by transition metal complexes derived from earth-abundant metals such as copper, iron, and nickel. This collaborative research project with the Université Grenoble Alpes in France will advance the understanding of how metal-ligand complex characteristics interface with different reagent...
The National Science Foundation (NSF) Division of Chemistry is providing a $315,000 Project Grant award to Muhlenberg College, Rhodes College, and the State University of New York at Cortland to study the catalytic efficiency of L-DOPA 2,3-dioxygenase enzymes. The 3-year collaborative research project, titled "Interrogating Catalytic Efficiency Through Kinetic, Structural and Small-Molecule Guided Investigation of L-DOPA 2,3-Dioxygenases", will systematically modify the size and electronic properties of catecholic carbon sources and the enzymes' structures to understand how these changes impact the effectiveness of the molecular conversions. Undergraduate students will gain interdisciplinary research experience and contribute to coursework at the participating institutions to broaden the reach of the original research. The project aims to expand the ability to predict and engineer extradiol dioxygenase enzymes, such as L-DOPA 2,3-dioxygenase, to utilize their powerful chemical capacity for refashioning naturally abundant catecholic carbon into useful materials.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $315.0k | 7/25/25 |