Project Grant 2213207
- This $700,000 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports Professor Jeffrey Rudolf at the University of Florida in his research on bacterial cytochrome P450 enzymes and their redox partners. The project aims to discover new natural products through identifying unique P450s in target bacteria genomes and understanding the molecular interactions between P450s and their redox proteins. This research will...
- This Project Grant award for $450,000 was provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The funding supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University to investigate a group of four enzymes that utilize a single iron atom and molecular oxygen to catalyze diverse chemical reactions. The goal is to elucidate the...
- This $180,000 Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program is funding a collaborative research effort between Drs. Keri Colabroy at Muhlenberg College, Larryn Peterson at Rhodes College, and Katherine Hicks at the State University of New York at Cortland. The project aims to systematically investigate how extradiol dioxygenase enzymes, such as L-DOPA 2,3-dioxygenase, utilize...
- The National Science Foundation's (NSF) Division of Chemistry awarded a $315,000 collaborative research grant under the Mathematical and Physical Sciences (CFDA 47.049) program to Muhlenberg College, Rhodes College, and the State University of New York at Cortland. This 3-year Project Grant, titled "COLLABORATIVE RESEARCH: RUI: INTERROGATING CATALYTIC EFFICIENCY THROUGH KINETIC, STRUCTURAL AND SMALL-MOLECULE GUIDED INVESTIGATION OF L-DOPA 2,3-DIOXYGENASES," aims to study how...
- This Project Grant award, valued at $450,000.00, was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program. The award, effective from August 1, 2024 to July 31, 2027, supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University. The objective of this research program is to elucidate the fundamental mechanisms by which a...
- The National Science Foundation (NSF) awarded a $599,999 project grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Santa Barbara (UCSB) and the University of Pittsburgh. The 3-year collaborative project aims to investigate the detailed mechanisms and origins of selectivity in recently developed enzymatic reactions with unnatural electron transfer pathways. The research team, led by Professors Yang and Liu, will integrate computational tools...
- The National Science Foundation awarded a $249,988 Project Grant to the University of North Carolina at Greensboro under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new photocatalysts for green oxidation processes. Professor Shabnam Hematian and her research team will study catalytic processes using light and oxygen to generate value-added chemicals from hydrocarbons. Specifically, the team will develop oxo-bridged heterobinuclear systems containing different metal...
- The National Science Foundation (NSF) awarded a $645,000 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program to Professor Makris at North Carolina State University. The grant supports research studying the structures and functions of a newly discovered class of enzymes from bacteria termed the Heme Oxygenase-Like Dimetal Oxidases/Oxygenases (HDOs). This research aims to provide a molecular rationale for how structurally similar HDO proteins can...
- Through a $575,000 National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) award, Cornell University will investigate ways of utilizing more abundant 1st row transition metals as alternatives to expensive precious metals commonly used in catalytic chemistry. The primary objective is to develop methods for modifying 1st row transition metal compounds with ligands to provide the chemical reactivity and covalency typically associated with 2nd and 3rd row transition...
- This $525,000 Project Grant awarded by the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), will fund research by Professor Holly Ellis and her team at East Carolina University to study the functional and structural properties of a recently identified enzyme system involved in persulfide oxidation. The project focuses on elucidating the catalytic mechanism and structural features of the mercaptopropionate...
This two-year, $249,840 Project Grant from the National Science Foundation's Mathematical and Physical Sciences Directorate will fund research into the contributions of adrenodoxin to cytochrome P450 catalysis, as well as related student support activities. Professor Michael Reddish of Appalachian State University will investigate how ferredoxin proteins enable cytochrome P450 enzymes to catalyze various chemical reactions important in nature and industrial processes. The research aims to determine if adrenodoxin promotes catalysis through conformational changes or altered substrate binding and reactivity. Understanding adrenodoxin's full roles could provide insight into cytochrome P450 function across domains of life. The grant also supports undergraduate research participation and development of an inclusive introductory chemistry curriculum to encourage diverse students to pursue science careers. Relevant context includes the NSF's mission to advance math and science and strengthen the U.S. innovation ecosystem through competitive peer-reviewed grants.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.8k | 4/4/22 |