This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $305,000 to Novaurum Biosciences Incorporated aims to develop a novel mammalian cell-based nano-biological coating for implantable medical devices. The key objectives are to: (1) characterize nanoparticles produced by different cells on orthopedic implant materials, (2) determine the antibacterial, anti-inflammatory, and tissue growth properties of the coated surfaces, and (3) evaluate the performance of the nanoparticles as the active ingredient. This project seeks to address the significant health and economic burden of implant-related infections, which cost over $8.6 billion annually in the U.S. The novel nano-biological coating is designed to inhibit biofilm formation and protect against antibiotic-resistant bacteria, while promoting biocompatibility and bone growth. The award has a performance period from March 1, 2025 to February 28, 2026, with plans for subawards.
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