Project Grant 2443053
- This Project Grant award for $450,000 was provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The funding supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University to investigate a group of four enzymes that utilize a single iron atom and molecular oxygen to catalyze diverse chemical reactions. The goal is to elucidate the...
- This Project Grant award, valued at $450,000.00, was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program. The award, effective from August 1, 2024 to July 31, 2027, supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University. The objective of this research program is to elucidate the fundamental mechanisms by which a...
- This federal Project Grant award for $647,301 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the understanding of iron-sulfur enzymes. The key objectives are to: Develop synthetic models of iron-sulfur enzyme active sites to characterize their molecular-level structures and reaction mechanisms, and Improve spectroscopic methods for analyzing the complex iron-sulfur clusters...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences Program (CFDA 47.049) provides $525,000 to East Carolina University (ECU) to study the functional and structural properties of enzymes involved in persulfide degradation. Specifically, Professor Holly Ellis and her research team at ECU will examine the catalytic mechanism and structural features of a mercaptopropionate dioxygenase (MDO) and a sulfurtransferase (ST) enzyme system that is critical...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049) provides $645,000 to North Carolina State University to study the structures and functions of a newly discovered class of enzymes called heme oxygenase-like dimetal oxidases/oxygenases (HDOs). The goal is to determine how structurally similar HDO proteins can catalyze radically different chemical transformations. The research will leverage bioinformatics,...
- The National Science Foundation (NSF) awarded a $479,856 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the University of Kansas Center for Research Inc. The grant, awarded on September 1, 2025 with an ultimate completion date of August 31, 2028, supports the development of new manganese and iron complexes that mimic intermediates in biological metal-dependent enzymes. The goal is to use these complexes to improve proton-coupled electron-transfer reactions,...
- This Project Grant award, funded by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), supports research at the University of Texas at Austin to study how the secondary coordination sphere (SCS) affects the activity of copper enzymes. The $594,870 award from August 1, 2024 to July 31, 2027 employs a novel biosynthetic approach to modulate copper enzyme activity, with potential applications in areas like...
- This $575,000 Project Grant award from the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Berkeley will support Professor Thomas Maimone's research on developing new synthetic strategies for constructing complex, nitrogen-containing molecules. The work aims to identify transformations that can efficiently produce unique target molecules with potential applications in pharmaceuticals, agrochemicals, and materials. The...
- This $575,000 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), will fund research at the University of California, San Diego to synthesize and study the reactivity of unusual main group elements stabilized by transition metal isocyanide complexes, from July 1, 2023 to June 30, 2026. Specifically, Professor Joshua S. Figueroa will manipulate boron monofluoride and diphosphorus molecules, which are...
- This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) to the University of California, Berkeley provides $780,000 in funding to investigate the molecular mechanisms of oxygen-dependent enzymes and develop synthetic mimics. The key objectives are to study a class of oxygen-dependent decarboxylase enzymes that utilize iron, manganese, or mixed metal active sites. This research aims to elucidate the critical oxygen-activated states of these enzymes, which have been challenging to characterize. The project will leverage a combination of enzymology, spectroscopy, and structural studies to understand the mechanisms of these oxygen-activating enzymes, which play important roles in biosynthesis of bioactive peptides. The award also supports training of graduate students and postdoctoral fellows in specialized techniques, as well as an outreach program to empower community college students. The project will run from August 1, 2025 through July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $780.0k | 7/16/25 |