This $487,795 award from the National Science Foundation (NSF) Engineering grant program (CFDA 47.041) supports Arizona State University in developing innovative ex vivo models of the tumor microenvironment (TME). The project aims to mechanistically understand how biophysical cues and signaling between stromal and immune cells contribute to the transition of tumor cells into an invasive phenotype, as well as explore how stromal cell function induces pathway signatures in tumor cells leading to...
The National Science Foundation (NSF) awarded a $125,731 Project Grant to the Kennesaw State University Research And Service Foundation, Inc. (KSU R&SF) on October 1, 2023. The award is funded through the NSF's Engineering program (CFDA 47.041), which supports a wide range of research and development activities to advance engineering knowledge and capabilities. This particular award will tackle the challenge of exploring, analyzing, and interpreting the complex interactions in the tumor...
This National Science Foundation (NSF) Engineering Program Project Grant, awarded to the University of South Florida (USF), aims to gain a fundamental understanding of the parameters of chimeric antigen receptors (CARs) that tune T cell responses, and to characterize how these parameters affect CAR engineered T cell function and fate. The $501,979 award, effective February 1, 2024 through January 31, 2029, will combine protein engineering, cell biology, and omics experiments to survey motif...
This $508,785 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research at Columbia University to investigate how the chemical composition and mechanical properties of biomaterials can be optimized to improve the production and function of T cells for use in cancer immunotherapy. The project aims to gain fundamental knowledge on how nutrient transport, particularly oxygen availability, within these biomaterials affects T cell...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This National Science Foundation (NSF) Project Grant, awarded under the Engineering program (CFDA 47.041), is supporting the development of innovative bacterial therapeutics for cancer immunotherapy. The $353,843 award will fund research to create a biosensing system that allows engineered E. coli bacteria to recognize and respond to extracellular cancer antigens, delivering targeted therapeutic payloads. In parallel, the project will engineer bacteria with improved tumor colonization...
This $305,000 federal Project Grant was awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) on April 15, 2025. The funding supports the development of a microchip-based technology by Cellecho, Inc. that leverages sound waves and electric fields to manipulate cells and sequentially deliver customizable combinations of genetic coding molecules. The broader goal is to make advanced cell engineering more accessible and...
Northeastern University was awarded a $398,495 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the NSF Engineering program (CFDA 47.041). The grant will fund the development of a microfluidic device capable of sorting effective T cells from ineffective T cells for use in cell therapy products. The project aims to improve the biomanufacturing process for engineering immune cell therapies, with a focus on...
The National Science Foundation awarded a $458,569 Project Grant to the University of Southern California under the Engineering federal grant program (CFDA 47.041) to support research developing next-generation chimeric antigen receptor T-cells for cancer immunotherapy using phosphoproteomics. Over a five-year period ending March 2027, the University of Southern California will identify signaling pathways that enhance tumor killing in CAR-T cells and define CAR signaling pathways enabling...
This $274,594 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports research and development of an innovative technology for cancer diagnosis and treatment. The project aims to improve molecular profiling and clinical laboratory testing of cancer samples by optimizing microdissection techniques. The research will focus on modeling and optimizing the opto-thermal-mechanical interactions involved in microdissection to...