This federal Project Grant award, totaling $400,000.00 and provided by the National Science Foundation (NSF) Integrative Activities (IA) program (CFDA 47.083), supports research on the bacterial cytochrome c biogenesis system II pathway. The project, led by the University of Delaware, aims to obtain a detailed, mechanistic understanding of this pathway through structure-function analysis. Key objectives include determining if the holocytochrome c synthase function is conserved despite protein variability, elucidating the system II/cytochrome c interaction domain to understand heme attachment specificity, and defining the evolution of bacterial cytochrome c biogenesis pathways. This work is expected to provide a mechanistic understanding of the system II pathway, develop tools for studying other cytochrome c biogenesis pathways, and lay the foundation for future research on the regulation and impact of cytochrome c biogenesis in bacterial metabolism and bioenergetics. The project period runs from March 15, 2025 to February 28, 2030.
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