This National Science Foundation (NSF) Project Grant award under CFDA #47.079, the Office of International Science and Engineering program, will provide $250,000 from August 2024 to July 2028 to the University of California, Irvine (UC Irvine). The project aims to use a rapid gene evolution system called Orthogonal DNA Replication (OrthoRep) to transform relatively simple artificial enzymes (metalloenzymes) into advanced biological enzymes with enhanced capabilities. This research will help understand how enzymes evolve over long timescales and provide insights for synthetic biology, biotechnology, medicine, agriculture, and the bioeconomy. The project is a collaborative effort between researchers in the U.S. and Switzerland, with NSF funding the U.S. investigator and the Swiss National Science Foundation supporting the Swiss partners.
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