This National Science Foundation project grant of $214,373 awarded to Arizona State University on April 1, 2022 through the Engineering (47.041) federal grant program will fund collaborative research examining the fluid dynamics of respiratory virus transport through lung liquid lining. Specifically, the award will support experiments and numerical modeling to capture the essential fluid interactions between lung surfactants and a model virus, simulating physiologically relevant scales....
This National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant award of $646,451 will support research to study how the mechanical properties of tissue regulate the function of neutrophils, a key type of innate immune cell. The research aims to define how matrix modulus, viscoelasticity, and dynamic tissue stiffening influence neutrophil behavior and inflammatory responses. This will be accomplished through three research objectives using novel engineered hydrogel...
The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $398,481 Project Grant to the University of South Carolina to conduct research on the interaction of viruses with indoor surfaces. The goal of this 3-year research project is to systematically address two key knowledge gaps: 1) understanding how viruses attach and detach from surfaces, and 2) understanding how indoor air dynamics affect virus transport to surfaces. The project will use experimental testing and...
This National Science Foundation (NSF) project grant under the Engineering program (CFDA 47.041) provides $616,151 to support fundamental research on the mechanisms by which mechanical forces regulate cell mechanics and multicellular organization. The award, effective from September 1, 2024 through August 31, 2027, will fund investigations into how intercellular adhesion proteins and cell mechanics influence the assembly and behavior of complex tissues. This interdisciplinary research...
This $349,999 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports an interdisciplinary research project to develop a novel biomaterial platform that simulates the extracellular matrix (ECM) environment of the human airway. The goal is to precisely control ECM composition and stiffness to investigate how these factors regulate airway basal stem cell (BC) self-renewal and differentiation. The research aims to provide new insights into lung...
This $342,318 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research focused on developing a novel theoretical formulation to model the mechanical deformation and interactions of biomembranes with transport and electrochemical processes. The research aims to gain a deeper understanding of cell functioning and implications for human health and disease. The project will integrate multiphysics concepts across mechanics, surface...
This $125,888 Project Grant award from the National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research by Yale University to investigate how the mechanical properties of host cells impact the infection and integration of the human immunodeficiency virus (HIV). The key objectives are to: 1) examine how HIV infection affects the mechanical and morphological attributes of the host cell nucleus, and 2) determine how the mechanical environment of...
This National Science Foundation (NSF) Project Grant award under the NSF Engineering program (CFDA 47.041) provides $349,237 to Rutgers, The State University to conduct collaborative research on the role of tension in the digestion of blood clots. The goal is to better understand how mechanical forces, such as blood flow and platelet contraction, impact the breakdown of blood clots, which is critical to preventing strokes and heart attacks. The multidisciplinary research approach across three...
The Trustees of the Stevens Institute of Technology received a $902,130 Project Grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation on January 1, 2022 to support research titled "BIOMECHANICS OF TENSION-INDUCED LUNG TISSUE FRACTURE AND SUBSEQUENT PULMONARY AIR LEAK." The research is funded through the NSF's Engineering program (CFDA 47.041) to improve understanding of lung tissue biomechanics and fracture. Specifically, the...
The National Science Foundation (NSF), through its Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), awarded a $451,093 Project Grant to the New Jersey Institute of Technology (NJIT) to investigate the interactions between flexible nanofilaments and biological cell membranes. The research aims to understand the mechanisms by which these nanofilaments adhere to and induce deformation in human and animal cells, leading to the organization and self-assembly of...