The National Science Foundation (NSF) awarded a $200,000 Project Grant under the Engineering program (CFDA 47.041) to the University of Connecticut (UConn) to develop a thermostable version of the CRISPR-Cas13 system for highly sensitive and robust RNA detection. The 3-year project aims to enhance the stability and sensitivity of the Cas13 enzyme, a cutting-edge technology for identifying disease-causing RNA, through mechanism-guided protein engineering. The goal is to combine the engineered Cas13 with innovative electrochemical devices to create next-generation diagnostic tools for rapid and accurate detection of various pathogens. The project will also involve educational outreach activities to engage high school and community college students, particularly from underrepresented backgrounds, in bioengineering research.
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