This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research at the University of Illinois to uncover mechanisms by which mechanical forces regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, effective September 1, 2024 through August 31, 2027, aims to investigate how intercellular adhesion proteins and cell mechanics coordinate to organize multicellular assemblies. The research will leverage molecular biology, bioengineering, materials science, and computational approaches to quantify the impact of altered force transduction mechanisms on cell mechanics, intercellular adhesion, and multicellular organization. The findings could lead to advances in tissue engineering and medicine to enhance national health and welfare. The program will also support the education and training of students from underrepresented groups across multiple disciplines.
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