The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program awarded a $637,920 Project Grant to Louisiana State University (LSU) with a performance period from August 1, 2024 to July 31, 2029. The grant supports research to understand the structure, function, and signaling pathways of the integrin αvβ8 receptor protein, which plays a critical role in nerve cell development and attachment to the extracellular matrix. The project aims to determine how this integrin adopts an extended, high-affinity conformation, differing from the typical bent, low-affinity integrin structure. The research will utilize biochemical, spectroscopic, and genetic approaches, and the results are expected to lead to new insights into integrin-ligand interactions that could inform the development of improved integrin-targeting therapeutics. The grant will also support the training of undergraduate, graduate, and high school students at LSU and in the local community in research methods and scientific career skills.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $637.9k | 7/30/24 |