Project Grant 2425703
- This federal Project Grant award of $300,000.00, awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041), will fund a collaborative research effort to develop chimeric antigen receptor (CAR)-engineered extracellular vesicles (EVs) derived from induced pluripotent stem cell (iPSC)-derived neutrophils. The objective is to engineer these CAR-associated EVs to possess enhanced targeting ability to glioblastoma, an aggressive type of brain cancer. The research team at...
- This $500,000 National Science Foundation project grant supports research to advance the biom anufacturing of extracellular vesicles through the integration of human induced pluripotent stem cell technology, genome engineering, and membrane nanofabrication. The primary recipient is Syracuse University, with Rochester Institute of Technology serving as a sub-awardee. Under the Biological Sciences program (CFDA 47.074), the grantees will work to generate a stable human iPSC line with enhanced EV...
- The National Science Foundation (NSF) is awarding a $360,000 Project Grant under the Engineering program (CFDA 47.041) to the University of Alabama. The grant, with a period of performance from September 1, 2025 to August 31, 2028, will support the development of a 3D engineered model that incorporates innate immune cells (macrophages and microglia) to study drug resistance in brain metastatic breast cancer (BMBC). This biomimetic model will be used to investigate how microglia and macrophages...
- This federal Project Grant award, valued at $641,936 and funded by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research), aims to develop novel strategies to program tumor-associated neutrophils as antitumor effector cells for the treatment of glioblastoma (GBM), the most aggressive type of brain cancer. The project will leverage synthetic biology, machine learning, and next-generation sequencing to interrogate tumor-associated neutrophils and develop methods to reprogram...
- The National Cancer Institute (NCI) awarded a $305,031 Project Grant to Round Table Research, Inc. under the Cancer Treatment Research program (CFDA 93.395) to advance extracellular vesicle (EV) therapy for the treatment of glioblastoma (GBM), an aggressive form of brain cancer. The funded project, conducted in collaboration with researchers at the University of North Carolina-Chapel Hill, seeks to develop engineered tumoricidal EVs derived from induced neural stem cells (iNSCs) as a promising...
- This Project Grant award from the National Science Foundation's Social, Behavioral, and Economic Sciences (CFDA 47.075) program provides $250,000 to Old Dominion University Research Foundation (ODURF) to develop low-cost mRNA-based manufacturing technologies for Chimeric Antigen Receptor (CAR) T-cell therapies. The research aims to address critical issues with current CAR T-cell manufacturing, including safety concerns with viral gene transfer and high costs associated with centralized...
- This $438,900 Project Grant was awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant funds research to develop a "three-cell (T-NK-macrophage) immunotherapy system" using chimeric antigen receptor (CAR) and synthetic cytokine receptor (SCR) technologies. The primary goal is to engineer the three immune cell types to function...
- This Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) aims to develop scalable manufacturing processes for engineered extracellular vesicles (EVs) that can serve as targeted drug delivery vehicles. The $2.55M grant to Vanderbilt University, awarded on January 1, 2024, will fund research to harness cellular processes for optimizing EV production, cargo loading, and cellular uptake. The long-term goal is to establish a biomanufacturing platform for...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $199,998 Project Grant to the University of North Carolina at Greensboro (UNC-G) to develop synthetic antigen-presenting cells (SAPCs) that can precisely control the immune response. The goal is to recreate the activities of natural dendritic cells, which play a critical role in balancing immune activation and suppression, to address the challenges associated with using dendritic cells in adoptive cell therapy....
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $304,951 to Neucore Bio, Inc. is focused on developing a scalable, cost-effective manufacturing process for extracellular vesicle (EV)-based gene therapy delivery systems targeting peripheral nervous system disorders. The research aims to optimize methods for EV isolation, purification, and cargo loading to improve therapeutic efficacy. Key objectives include establishing...
This $350,000 federal Project Grant was awarded on September 1, 2025 by the National Science Foundation (CFDA 47.041 Engineering) to Florida State University. The objective is to engineer chimeric antigen receptor (CAR)-associated extracellular vesicles (EVs) derived from induced pluripotent stem cell (iPSC)-derived neutrophils (NEU) that can better target glioblastoma, a type of brain cancer. The project will develop CAR-engineered EVs, introduce potentially toxic cargos, and evaluate their effectiveness against glioblastoma cells and brain organoid models. Educational outreach activities including high school engagement, undergraduate research, and industrial employee training will complement the research efforts. The goal is to create CAR-NEU EVs that can effectively deliver a toxic payload to glioblastoma tumors.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $350.0k | 8/27/25 |