This Project Grant award, valued at $200,812.00, was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The award supports a collaborative research project between the University of California, San Diego; Xavier University of Louisiana; and the University of California, Irvine. The project aims to develop mathematical models describing the evolution of mutant cells in the human blood system, bridging between experimental mouse data and epidemiological observations in human populations. The overarching goal is to gain deeper insights into the mechanisms driving the emergence and persistence of mutant cells in non-malignant human tissues, which could inform strategies to reduce mutant cell burden and associated chronic health conditions, including cancer risk. The project will leverage expertise across evolutionary dynamics, hematopoietic systems, and applied mathematics to address this important public health challenge. The award period runs from October 1, 2024 to September 30, 2027.
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