The National Science Foundation (NSF) awarded a $116,354 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of Dayton Research Institute Division. The grant will fund a 3-year collaborative research project to develop a mathematical theory for the biological concept of modularity in complex dynamic regulatory networks. The research aims to define modular structures in biological systems in a mathematically rigorous way, determine why modularity is advantageous to organisms, and leverage modularity to advance the understanding of molecular systems. The project will involve computational, experimental, and theoretical studies, and will demonstrate the validity of the approach through in vivo analyses in the plant Arabidopsis and in silico analyses in the animal model axolotl. The research is expected to yield novel biological insights, advance knowledge in network analysis, systems biology, and developmental biology, and contribute to the interdisciplinary training of STEM workforce through student involvement.
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