The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $199,999 Project Grant to Clarkson University to develop a highly selective and sensitive biosensor for the rapid detection of the microcystin synthetase (MCY) gene, which is essential for the production of harmful microcystins during algal blooms. The overarching goal is to create a CRISPR-Cas12a-powered biosensing system coupled with a novel magnetic bead-based reporter to enable early warning of toxic algal...
This National Science Foundation (NSF) CAREER program Project Grant award for $242,687 supports the development of an ultrasensitive nanopore biosensor technology for point-of-care detection and quantification of multiple infectious disease biomarkers. The award, under NSF's Engineering program (CFDA 47.041), aims to create a next-generation nanopore sensing platform that can achieve sub-femtomolar detection limits, enabling rapid and accurate diagnosis of infectious diseases at the point of...
Clarkson University received a $295,905 Project Grant award from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems on May 1, 2021 to fund the research project "COLLABORATIVE RESEARCH: A MULTIPLEXED MICROBIOSENSING PLATFORM FOR UNDERSTANDING REAL TIME NEUROTRANSMITTER DYNAMICS IN THE BRAIN." The award will support Clarkson University's research efforts through April 30, 2024 under the NSF's Engineering (ENG) program (CFDA...
This $1,200,000 Project Grant awarded by the National Science Foundation (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) will support the development of innovative sensing technologies that integrate DNA nanotechnology and CMOS electronics to enable more frequent blood and urine testing for early disease detection. The 4-year project aims to: Develop molecular engineering techniques using DNA origami nanotechnology to perform in-situ signal amplification for...
This $228,697 National Science Foundation award under the Engineering program (CFDA 47.041) will support the development of an optical biosensor technology to facilitate drug screening and validation efforts. Auctus Biologics, Inc. will utilize a proprietary temperature, pH, and chemically stable protein composed of two fragments that bind with antibody-like affinity and specificity. Over the one-year period ending January 2023, the company will establish the technology's suitability for...
The National Science Foundation (NSF) Division of Chemistry awarded a $420,000 Project Grant to the University of Utah from August 1, 2023 to July 31, 2026 under the Mathematical and Physical Sciences program (CFDA 47.049). The funding supports the development of a novel optical biosensor capable of detecting and quantifying a wide range of biological molecules, including biomarkers found in bodily fluids. The project leverages second harmonic generation (SHG) and optical heterodyning techniques...
This $461,575 Project Grant, awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), supports research into how bacterial enzymes recognize and prevent the use of toxic D-amino acids in protein synthesis. The project, led by Earlham College, a private non-profit educational institution, aims to investigate the enzyme ProXP-X, which can bind both L- and D-amino acids, and determine how it protects bacterial cells from D-amino acid toxicity. The research will...
This $1,016,000.00 Project Grant award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program will fund the development and application of a low-cost, portable biosensing platform for detecting and monitoring waterborne pathogens in aquaculture and coastal environments. The University of Massachusetts Lowell, as the prime awardee, will lead the effort to adapt its patented biosensing technology to enable real-time pathogen detection and...
This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) will support research to investigate the roles of amino acid isomerization, a chemical modification that affects the structure and function of cell-cell signaling peptides. The $681,070 award to the Board of Regents of the University of Nebraska, which operates as the University of Nebraska, aims to provide critical insights into how living systems alter their cellular communication...