Project Grant 2419566

Award Date 9/1/24
Completion Date 8/31/27
Dollars Obligated $596K
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
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This $595,829 federal project grant was awarded by the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program to The Trustees of the University of Pennsylvania to fund research on the propulsion of synthetic cell-like capsules driven by biochemical catalysis. The key objectives are to:

  1. Measure the motility of single enzyme-functionalized capsules across a range of enzyme-substrate systems and quantify the directional motion of asymmetric "Janus" capsules in substrate gradients.

  2. Determine the ensemble motion of capsule mixtures with different volume fractions of active and passive particles to understand how motility can be used to separate and organize multi-particle assemblies.

  3. Develop communication systems where one capsule can secrete a substrate to drive the motion of a neighboring capsule, and explore how these motile synthetic capsules can interface with biological cells.

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