The National Science Foundation (NSF), through its Division of Chemistry's "Chemistry of Life Processes Program," awarded a $469,645 Project Grant to Dr. Colin Kinz-Thompson at Rutgers University-Newark. The grant, with a performance period from May 1, 2025 to April 30, 2030, will fund research to investigate the mechanistic roles of receptor oligomerization in molecular signaling processes. The project aims to determine how bacteria accurately sense their surroundings and develop...
This Project Grant award of $510,759 from the National Science Foundation (NSF) Division of Chemistry supports a research collaboration led by Professors Andrew Mitchell of Illinois State University and Dean Tantillo of UC-Davis. The goal is to develop new chemical reactions with connections to biology, medicine, physics, materials, and environmental sustainability. Key products include: Advancing oxidopyrylium-based [5+2] cycloaddition reactions to construct important heterocyclic small...
The National Science Foundation (NSF) awarded a $200,055 Project Grant under the Biological Sciences (CFDA 47.074) program to Purdue University. The grant funding supports a 5-year research project focused on studying the assembly and supramolecular organization of bacterial microcompartments. This research aims to develop a model for how these large protein assemblies are built, mature, and function, with the goal of understanding the mechanisms of both beneficial and pathogenic...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $373,168 supports collaborative research between the University of Wisconsin-Milwaukee and Northeastern Illinois University to understand the molecular mechanisms behind how myxobacteria use phytochromes to sense light and convert that signal into developmental changes, such as fruiting body formation. The research will utilize cutting-edge techniques including time-resolved X-ray...
This $447,000 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), will support research at Haverford College from December 2022 through February 2026. The research team, led by Dr. Louise Charkoudian, will investigate type II polyketide biosynthetic enzyme assemblies across bacterial species to leverage their capabilities for sustainable chemical production. Undergraduate students will gain research...
This Project Grant award of $222,000 from the National Science Foundation's (NSF) Mathematical and Physical Sciences (47.049 CFDA) program supports research at Bryant University to develop new chemical biology tools for studying peptidoglycan metabolism in bacteria. Led by Dr. Christopher Reid, the project aims to expand on the team's previous work with the inhibitor masarimycin to create an array of novel glycosyl triazole and diamide compounds that can probe the degradative steps of...
The National Science Foundation (NSF) awarded a $626,831 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Wisconsin-Milwaukee (UWM) to conduct collaborative research on the molecular mechanisms behind how certain bacteria use light-sensing proteins called phytochromes to regulate essential developmental processes. The project aims to use advanced structural biology techniques like cryo-electron microscopy and time-resolved X-ray crystallography to study...
This National Science Foundation Project Grant of $921,054 supports research to develop new biological functions through engineering plant hormone receptors. Led by the Regents of the University of California, Riverside under the Biological Sciences program (CFDA 47.074), the project engineers plant sensors to recognize pharmaceuticals and dietary molecules. It then uses these sensors to design "sentinel cells" that indicate molecule presence through color changes. Specifically, the...
This National Science Foundation (NSF) Project Grant under the Biological Sciences program, awarded to the San Diego State University Research Foundation, will support research to investigate how microbial social interactions within soil communities influence ecosystem-level carbon, nitrogen, and phosphorus cycling. The $982,308 award, effective April 1, 2024 through March 31, 2027, will combine molecular and computational approaches to study bacterial communication and division of labor...
Colorado State University Sponsored Programs Division was awarded a three-year $406,500 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program to develop chemical tools to investigate phosphatidylinositol mannosides (PIMs) in the Corynebacterineae suborder of bacteria. Under the award beginning July 1, 2023, Professors Benjamin Swarts of Central Michigan University and Mary Jackson of Colorado State University will synthesize carbohydrate-based probes...