This Project Grant award for $450,000 was provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The funding supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University to investigate a group of four enzymes that utilize a single iron atom and molecular oxygen to catalyze diverse chemical reactions. The goal is to elucidate the fundamental mechanisms by which these enzymes activate oxygen and achieve varied reaction outcomes, with potential applications in the production of antibiotics, antimalarial agents, and other physiologically relevant molecules. The research will integrate educational activities to disseminate cutting-edge results and research skills to students at the graduate, undergraduate, and K-12 levels. The award period runs from August 1, 2024 to July 31, 2027.