The National Science Foundation (NSF) Division of Chemistry awarded a $431,392 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the Georgia TECH Research Corporation (parent organization Georgia Institute of Technology). The 3-year grant, beginning July 1, 2024, supports collaborative research on the conformational dynamics and protein evolution of archaeal protein tyrosine phosphatases (PTPs). The research, conducted by professors at Georgia Tech and Utah State University, aims to quantitatively characterize the evolution of loop motion and allostery in archaeal PTPs using advanced biomolecular simulations, X-ray crystallography, kinetic characterization, and NMR spectroscopy. This work seeks to provide fundamental insights into enzyme evolution and identify features that can be exploited for protein engineering. The grant also includes outreach and mentorship activities to increase participation of underrepresented students in STEM fields, as well as efforts to bring the research to the general public.
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