Project Grant 2412519
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $393,371 to the Texas A&M Engineering Experiment Station (Tees) to conduct research on the mechanics of the nuclear envelope (NE) - the physical barrier between the cytoplasm and the nucleus in eukaryotic cells. The overarching goals are to: 1) discover the link between NE structure and its mechanical properties, and 2) identify principles for designing new biologically-inspired...
- The National Science Foundation awarded a $409,795 Project Grant to the University of Houston System under the Engineering federal grant program (CFDA 47.041) to support fundamental research on the mechanics of active biological membranes from May 1, 2023 to April 30, 2026. The research aims to establish a rigorous theoretical framework integrating continuum mechanics and non-equilibrium statistical mechanics to model active membranes. Specifically, the university will focus on entropic...
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
- The National Science Foundation (NSF) awarded a $297,984 Project Grant under the Engineering program (CFDA 47.041) to the University of Texas Health Science Center at Houston (UTHealth). The grant supports collaborative research to quantify the mechanical forces inside living cells and determine how changes in these forces impact the production and secretion of proteins that shape the cellular environment. The goal is to develop predictive tools using mechanical forces to control cell...
- This $462,332 National Science Foundation project grant supports research into biomechanical regulation of intranuclear elastography and gene location in single cells. The NSF Division of Civil, Mechanical, and Manufacturing Innovation awarded this funding through the Engineering program (CFDA 47.041) to The Regents of the University of Colorado on September 1, 2022 for completion by August 31, 2025. The University of Colorado will conduct fundamental research measuring gene expression and...
- This federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $374,132 to the University of Houston System to conduct research on the fundamental mechanisms governing the nucleation and growth of liquid-like macromolecular condensed phases. The project aims to unlock new possibilities for designing drug delivery systems, improving food preservation, and developing self-healing materials, while also providing insights into cellular...
- This Project Grant award, titled "MECHALINC: MECHANISTICS OF LINC-MEDIATED FORCE TRANSMISSION", was provided by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) federal grant program. The $1,117,664 award, with a project period from February 15, 2025 to January 31, 2029, will support research to investigate the physical and molecular mechanisms underlying how cells transmit mechanical forces from their environment to the cell nucleus. The project aims...
- This $395,749 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) will enable researchers at Syracuse University to develop a comprehensive physics framework for understanding how cell nuclei and tissues adapt to extreme mechanical stress. The project aims to investigate the mechanisms by which cell nuclei deform and respond to compression, as well as how tissue-level forces impact chromatin organization. The...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports fundamental research to develop a general elastic framework and computational models to understand the mechanical instabilities and surface morphologies of self-assembled thin solid films, such as lipid monolayers. The $600,258 award, active from May 1, 2025 to April 30, 2028, aims to unify the understanding of out-of-plane buckling and in-plane relaxation phenomena observed in highly...
- This National Science Foundation (NSF) Project Grant under the Engineering program (CFDA 47.041) will provide $370,974 in funding to the University of Houston System for research aimed at advancing the understanding of quantum materials. The research will develop new models and methods for designing quantum materials by linking continuum mechanics with quantum field, electric field, and magnetic field interactions. This work will provide fresh perspectives on improving properties like...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) provides $279,226 in funding from August 1, 2024 to July 31, 2027 to the University of Houston System for a collaborative research project titled "Mechanics of the Topologically Complex Nuclear Envelope." The project aims to develop new fundamental insights into the mechanical properties of the nuclear envelope, which is essential for the survival and function of eukaryotic cells. The research will experimentally quantify spatial fluctuations in the nuclear envelope under various perturbations and use computational modeling to interpret the observations and understand the underlying mechanics and forces. The overarching goal is to explain how passive forces, active forces, and geometry impact the mechanics of the nuclear envelope. This research will advance the understanding of the interplay between geometry, topology, and mechanics in soft 2D materials and provide insights for developing a new generation of biologically inspired complex materials.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $279.2k | 7/10/24 |