This federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (MPS) program provides $438,249 to the University of Washington to research the mechanisms and biological rationale underlying oscillations in cellular metabolites, including critical energy molecules like ATP. The project aims to model regulatory oscillations, characterize oscillations in replication fork velocity, measure cell-cycle dependent expression of metabolic enzymes, and directly measure oscillations in metabolite levels. In addition to the scientific research, the award supports the training of graduate and undergraduate students, including researchers from underrepresented groups. The project will run from July 2024 through June 2028, expanding fundamental understanding of cellular metabolic regulation with potential implications for diverse biological and biomedical applications.
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