This Project Grant award from the National Science Foundation (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) provides $785,000 to Professor Pier Alexandre Champagne at the New Jersey Institute of Technology (NJIT) to advance the chemical understanding of reactive sulfur species. The key objectives are to: Develop new synthetic donors of reactive sulfur species and use them to probe the behavior of these biochemically important but poorly understood compounds. Apply...
This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $154,000 in funding to Boston University from July 1, 2024 to June 30, 2027 to conduct research on protein aggregation and liquid-liquid phase separation (LLPS). The project, a collaborative effort between US and French researchers, aims to elucidate how protein-rich droplets can promote the pathological aggregation of proteins associated with neurodegenerative diseases,...
This Project Grant award for $450,000 was provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The funding supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University to investigate a group of four enzymes that utilize a single iron atom and molecular oxygen to catalyze diverse chemical reactions. The goal is to elucidate the...
This National Science Foundation Project Grant of $600,000 will support research at Cornell University from June 2022 through May 2024 under the Biological Sciences program (CFDA 47.074). The university will conduct cryogenic electron microscopy analysis of the chloroplast CLP protease system in Arabidopsis thaliana to determine the three-dimensional structure of the endogenous ~1,000 kDa CLP protease-chaperone complex. The research aims to unravel the structural details of this chloroplast...
This Project Grant award, valued at $450,000.00, was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program. The award, effective from August 1, 2024 to July 31, 2027, supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University. The objective of this research program is to elucidate the fundamental mechanisms by which a...
The National Science Foundation (NSF), through its Mathematical and Physical Sciences program (CFDA 47.049), awarded a $234,925 Project Grant to the University of Florida. The funding supports research conducted by Professor Kate Carroll to investigate post-translational protein cysteine modifications and the chemical reactivity of sulfur. The research explores how different cysteine thiol group modifications impact the properties of the sulfur atom, which is essential for understanding the role...
This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
This Project Grant award, funded by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), supports research at the University of Texas at Austin to study how the secondary coordination sphere (SCS) affects the activity of copper enzymes. The $594,870 award from August 1, 2024 to July 31, 2027 employs a novel biosynthetic approach to modulate copper enzyme activity, with potential applications in areas like...
This Project Grant award of $600,000 from the National Science Foundation's (NSF) Division of Chemistry was granted to Texas A&M University on July 15, 2025. The award supports fundamental research into the reactivity and applications of transition metal complexes containing boron-metal bonds, known as "boryl-centered pincer complexes." The key objectives of this 3-year project are to: Develop a deeper understanding of the unique reactivity and bond-forming/breaking mechanisms of...
This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...