Project Grant 2408928

Award Date 8/1/24
Completion Date 7/31/27
Dollars Obligated $220K
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Berkeley, CA 94720, USA
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This federal Project Grant award for $220,000, provided by the National Science Foundation's (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049), aims to deliver a comprehensive mathematical and computational framework for optimizing the design of next-generation stents. Key products and services to be provided under this 3-year award (August 1, 2024 to July 31, 2027) include:

  1. Developing a reduced model optimization module for the optimal design of mesh-like stent structures, leveraging sophisticated mathematical approaches for speed and accuracy.
  2. Creating a fluid-stent-poroelastic structure interaction module to simulate the interaction between blood flow, artery walls, and implanted stents, accounting for the multi-layered poroelastic structure of arterial walls.
  3. Establishing a nonlinear advection-reaction-diffusion module to simulate drug transport within the vascular wall and lumen for drug-eluting stents.

The project will produce digital stent prototypes ready for 3D printing, tailored to specific patient geometries and applications. It will also facilitate interdisciplinary mentoring of students and postdoctoral researchers by the team of a mathematician, an engineer, and an interventional cardiologist.

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