Project Grant 2406996
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) provides $778,507 to Wayne State University to develop novel chemical tools to study how the addition of phosphate groups to histidine amino acids in proteins affects their biological functions in mammalian cells. The principal investigator, Dr. Mary Kay Pflum, is utilizing kinase-catalyzed labeling with ATP analogs to investigate histidine phosphorylation, which is less...
- The National Science Foundation Division of Chemistry awarded a $494,550 Project Grant to the University of Georgia Research Foundation to support research investigating new protein post-translational modifications derived from valine metabolism. Under the Mathematical and Physical Sciences federal grant program (CFDA 47.049), principal investigator Y. George Zheng and early career trainees will identify and validate two novel post-translational modifications, lysine methacrylylation and...
- This $500,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) will fund Dr. Nicholas Truex at the University of South Carolina to investigate synthetic protein switches. The research aims to characterize the molecular interactions that enable these proteins to adopt two distinct folded structures, utilizing non-natural amino acids to dissect their conformation and stability. Key experimental techniques will include...
- The National Science Foundation (NSF) Division of Chemistry awarded a $460,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to Drs. Harish Vashisth from the University of New Hampshire and Esteban A Orellana Vinueza from Dartmouth College. The 3-year grant, effective September 1, 2025, supports collaborative research to study how chemical modifications to transfer RNA (tRNA) bases affect the structure, folding, and dynamics of tRNA isodecoders, which are...
- The University of Pittsburgh received a $537,317 Project Grant award from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences federal grant program (CFDA 47.049). The grant supports the development of activity-based probes for genome-modifying enzymes through an interdisciplinary research project led by Dr. Kabirul Islam. The project aims to uncover novel DNA-modifying enzymes that protect and control genetic information through organic chemistry,...
- This $605,020 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports research conducted by Professor Byron Purse of the Department of Chemistry and Biochemistry at San Diego State University. The research aims to determine how molecular structure and local environment influence key properties of fluorescent nucleobase analogues (FBAs), which are synthetic molecules that mimic natural genetic bases and enable sensitive...
- The University of Virginia received a $483,000 Project Grant award from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to develop new enantioselective fluorescent sensors for amino acids. Professor Lin Pu and researchers will further optimize a 1,1'-binaphthyl-coumarin-based fluorescent probe and its pseudo-enantiomer to simultaneously determine the concentration and enantiomeric composition of amino acid...
- The National Science Foundation (NSF) Division of Chemistry awarded a 3-year, $389,999 Project Grant to Florida State University (FSU) under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new approaches to characterize the structural dynamics of proteins that play critical roles in chemical reactions within biological cells. The project, led by Dr. Christian Bleiholder, will combine and enhance the capabilities of tandem-ion mobility spectrometry coupled with mass...
- This National Science Foundation (NSF) Project Grant award under the Mathematical and Physical Sciences program (CFDA 47.049) provides $343,638 to Texas A&M University-Commerce to conduct research on the thermochemistry, reaction dynamics, and conformational changes associated with the collisional activation of peptide ternary complexes and recombinant tagged proteins. The key products and services to be delivered through this 3-year grant include: Developing new zinc- and nickel-binding...
- This $157,688 National Science Foundation Integrative Activities award will support the development of bioactive surfaces through non-covalent protein-polymer conjugation strategies at the University of Southern Mississippi from June 2023 through May 2025. The goal of the project is to create regenerative protein-decorated surfaces with ease of removal and reapplication of active recombinant proteins for applications such as self-cleaning, antibacterial, and therapeutic surfaces. The Principal...
This $574,915 Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) supports research by Professor Monika Raj of Emory University to develop new chemical probes and strategies for detecting and studying modifications to the amino acid histidine in proteins. The goal is to create novel chemical probes capable of selectively labeling modified histidine residues in proteins and capturing the protein-protein interactions influenced by these histidine modifications. This research has the potential to improve understanding of how histidine modifications regulate cellular signaling processes and contribute to various diseases. The project also includes efforts to engage underrepresented groups in STEM fields through research training and outreach activities.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $574.9k | 7/3/24 |