This Project Grant award from the National Science Foundation's Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports a collaborative research effort led by Emory University and the University of Illinois Chicago to design and develop peptide-based filamentous nanomaterials.
The $300,000 award, effective from August 1, 2024 to July 31, 2027, will leverage computational methods to systematically explore the energetics and structural designability of peptide assemblies. The goal is to establish a general scientific approach for the design of peptide-based filaments with potential applications in synthetic tissues, drug delivery, and as vaccines/antibiotics. Key project activities include validating computational models using structurally characterized peptide filaments, and determining the atomic-level structures of the designed peptide assemblies using cryo-electron microscopy. The broader impacts of this research include educating undergraduate, graduate, and postdoctoral researchers, as well as engaging the general public through exhibits at the Atlanta Science Festival.
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