This $280,000 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a new mass spectrometry-based strategy to enable the analysis of RNA-binding proteins involved in cell-cell communication. Specifically, researchers at Purdue University will use the funding to introduce a chemical tag on RNAs in extracellular vesicles (EVs) in order to isolate and analyze the proteins that interact with these RNAs when they are transferred between cells. This interdisciplinary project incorporates elements of chemical biology, instrumentation, and bioinformatics, and includes education and outreach activities to engage undergraduate students in the research. The goal is to provide dynamic insights into the molecular mechanisms underlying the important role of EV RNAs in intercellular communication. The grant period runs from September 1, 2024 to August 31, 2027.
Generated 2/25/25, 5:11 AM