This $390,000 federal Project Grant awarded by the National Science Foundation (NSF) Division of Chemistry enables researchers at Fairleigh Dickinson University to develop a new methodology for quantitatively assessing the complex retention mechanisms in hydrophilic interaction chromatography (HILIC). The key objectives are to:
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Quantify the contributions of hydrophilic partitioning, surface adsorption, and electrostatic interactions to overall analyte retention in HILIC separations. This will allow unambiguous identification of the primary retention mechanism for different compounds.
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Provide new insights into selectivity on diverse HILIC stationary phases to facilitate column selection and method development.
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Establish a mechanistic-based classification system for HILIC stationary phases.
The 3-year project, running from July 2024 to June 2027, will engage graduate and undergraduate students, particularly from underrepresented groups, in advanced training in separation science and chemical analysis. The expected research outcomes will lead to a better fundamental understanding of HILIC principles, benefitting biomedical, environmental, and pharmaceutical applications that rely on these chromatographic techniques.
Generated 3/4/25, 8:43 AM