This $597,945 federal Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports research by Tobias W. Giessen at the University of Michigan, Ann Arbor to investigate the structure and function of peptide-modifying enzyme filaments found in bacteria and archaea. The proposed work will generate new insights into the self-assembly and catalytic activity of these filamentous enzymes, which could enable their use in sustainable biocatalysis and chemoenzymatic synthesis applications. The project will also provide specialized training in cryo-electron microscopy and the biochemical/biophysical analysis of protein filaments for undergraduates and postdoctoral fellows. There are no planned subawards for this 3-year award, which commenced on May 1, 2024.
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