This Project Grant award from the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program provides $451,460 to Emory University to conduct collaborative research on the computational design of peptide-based filamentous nanomaterials. The project, led by researchers from Emory University and the University of Illinois Chicago, aims to develop a general scientific approach to computation-guided design of...
This $236,662 National Science Foundation award through the Mathematical and Physical Sciences program (CFDA 47.049) funds research at Emory University to develop novel biomimetic materials capable of simultaneously encoding both nucleic acid and protein information codes to control assembly and function. Specifically, the award supports exploration of "bilingual biopolymers" using peptide nucleic acid as a scaffold to direct structure based on both peptide and nucleic acid...
This Project Grant award from the National Science Foundation's Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports a collaborative research effort led by Emory University and the University of Illinois Chicago to design and develop peptide-based filamentous nanomaterials. The $300,000 award, effective from August 1, 2024 to July 31, 2027, will leverage computational methods to systematically explore the energetics and structural designability of...
This Project Grant award, provided by the National Science Foundation's Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049), supports research at Emory University to develop practical methods for conducting synthetic transformations using low catalyst loadings. The $575,000 grant, awarded on August 1, 2024, aims to enable more sustainable and commercially viable chemical synthesis processes, with a focus on advancing next-generation drug candidate...
This Project Grant from the National Science Foundation Division of Chemistry provides $500,000 to New York University from August 1, 2021 through July 31, 2024 to support research titled "Towards a Greener Approach for Chemical Synthesis of Peptides." The award is part of the Mathematical and Physical Sciences program (CFDA 47.049), which aims to promote progress in these scientific fields and strengthen the national scientific enterprise through increasing knowledge and enhancing...
This $146,816 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of novel peptide catalysts for stereo- and site-selective carbon-carbon bond formation reactions. The project leverages automated fast-flow peptide synthesis and machine learning to access a broad chemical space of mid-length peptide catalysts containing non-natural amino acids. One research direction focuses on...
The National Science Foundation, through its Division of Chemistry and the Mathematical and Physical Sciences program (CFDA 47.049), awarded a $577,690 Project Grant to the University of North Carolina at Chapel Hill from July 1, 2023 through June 30, 2027. The grant supports research to characterize the biosynthetic pathways of dehydroamino acids in nonribosomal peptides, which are biologically and industrially important natural products. The research aims to understand the molecular details of...
This $597,945 federal Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports research by Tobias W. Giessen at the University of Michigan, Ann Arbor to investigate the structure and function of peptide-modifying enzyme filaments found in bacteria and archaea. The proposed work will generate new insights into the self-assembly and catalytic activity of these filamentous enzymes, which...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,155,000.00 to the University of Utah to develop new chemical methods for the practical synthesis of bioactive cyclic and microcin J25-inspired lasso peptide scaffolds. The 5-year project aims to develop strategies to prepare cyclic/bicyclic peptides and demonstrate their potential as antimicrobial peptide therapeutic leads,...
The federal Project Grant award R35GM156435 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The $259,966 grant, awarded on April 21, 2025, supports the development of new synthetic strategies to functionalize pyridine and diazine heterocycles, which are key structural components in many FDA-approved drugs. The research aims to enable medicinal chemists to directly and selectively install a range...